2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Cl-HIBO

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties.

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Cl-HIBO Chemical Structure

Cl-HIBO Chemical Structure

CAS No. : 909400-43-7

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Based on 1 publication(s) in Google Scholar

Cl-HIBO Related Antibodies

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Description

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

IC50 & Target

EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]
Cellular Effect
Cell Line Type Value Description References
Oocyte EC50
1.7 μM
Compound: 3 (Cl-HIBO)
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes
[PMID: 12747796]
Oocyte EC50
1.7 μM
Compound: 3, Cl-HIBO
Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA2(Q)i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
[PMID: 21067182]
Oocyte EC50
1300 μM
Compound: 3 (Cl-HIBO)
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes
[PMID: 12747796]
Oocyte EC50
1300 μM
Compound: 3, Cl-HIBO
Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA4i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
[PMID: 21067182]
Oocyte EC50
2700 μM
Compound: 3 (Cl-HIBO)
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes
[PMID: 12747796]
Oocyte EC50
2700 μM
Compound: 3, Cl-HIBO
Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA3i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
[PMID: 21067182]
Oocyte EC50
4.7 μM
Compound: 3 (Cl-HIBO)
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 1 (GluR1) using rat cortical slice model in Xenopus laevis oocytes
[PMID: 12747796]
Oocyte EC50
4.7 μM
Compound: 3, Cl-HIBO
Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
Agonist activity at rat recombinant GluA1i expressed in Xenopus laevis oocytes by two-electrode voltage clamp assay
[PMID: 21067182]
In Vitro

Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cl-HIBO Related Antibodies
Molecular Weight

206.58

Formula

C6H7ClN2O4
CAS No.
Appearance

Solid

Color

Light brown to gray

SMILES

O=C(O)C(N)CC(ON1)=C(Cl)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 4.5 mg/mL (21.78 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8407 mL 24.2037 mL 48.4074 mL
5 mM 0.9681 mL 4.8407 mL 9.6815 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8407 mL 24.2037 mL 48.4074 mL 121.0185 mL
5 mM 0.9681 mL 4.8407 mL 9.6815 mL 24.2037 mL
10 mM 0.4841 mL 2.4204 mL 4.8407 mL 12.1018 mL
15 mM 0.3227 mL 1.6136 mL 3.2272 mL 8.0679 mL
20 mM 0.2420 mL 1.2102 mL 2.4204 mL 6.0509 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cl-HIBO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-HIBO909400-43-7iGluRIonotropic glutamate receptorssubtypeselectivedesensitizingneurotoxicityInhibitorinhibitorinhibit

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