CL 218872

Name: CL 218872
Brand: MedChemExpress
SKU: HY-103505
Rating: 4.5 (1 reviews)

Cat. No.: HY-103505 Purity: 98.01%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

CL 218872 is an orally active and selective ligand for the benzodiazepine receptor subtype BZ₁. CL 218872 exhibits anxiolytic, sedative and anticonvulsant activities. CL 218872 can be used in researches of anxiety related disorders and epilepsy.

For research use only. We do not sell to patients.

CL 218872 Chemical Structure

CAS No. : 66548-69-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

In Vivo

CL 218872 (ED₅₀ of 58 mg/kg; p.o.) inhibits footshock-induced fighting in mice with 50-fold lower potency than Diazepam^[2].
CL 218872 (5-20 mg/kg; p.o.) reduces locomotor activity, head-dipping, and rearing in rats, with sedative effects reversed by Flumazenil (HY-B0009)^[3].
CL 218872 (20-40 mg/kg; s.c.) antagonizes Diazepam-induced loss of righting reflex in mice^[4].
CL 218872 (5-20 mg/kg; i.p.) impairs place learning in rats, increasing swim path length and reducing quadrant bias in probe trials^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male CD Sprague-Dawley rats (200-300 g, sex: male, weight: 200-300 g)^[2]
Dosage:	5 mg/kg, 20 mg/kg
Administration:	Oral administration
Result:	Reduced locomotor activity and impaired motor coordination.

Molecular Weight

278.24

Formula

C₁₃H₉F₃N₄

CAS No.

66548-69-4

Appearance

Solid

Color

Light yellow to brown

SMILES

FC(C1=CC(C2=NN3C(C=C2)=NN=C3C)=CC=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 16.67 mg/mL (59.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5940 mL	17.9701 mL	35.9402 mL
5 mM	0.7188 mL	3.5940 mL	7.1880 mL
10 mM	0.3594 mL	1.7970 mL	3.5940 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (287 KB) SDS (393 KB)

COA (248 KB) HNMR (119 KB) RP-HPLC (247 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Squires RF, et al. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol Biochem Behav. 1979 May;10(5):825-30. [Content Brief]

[2]. Oakley NR, et al. The benzodiazepine receptor ligand CL218,872 has both anxiolytic and sedative properties in rodents. Neuropharmacology. 1984 Jul;23(7A):797-802. [Content Brief]

[3]. File SE, et al. The sedative effects of CL 218,872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists. Psychopharmacology (Berl). 1985;85(3):295-300. [Content Brief]

[4]. Gee KW, et al. CL 218872 antagonism of diazepam induced loss of righting reflex: evidence for partial agonistic activity at the benzodiazepine receptor. Life Sci. 1983 Feb 28;32(9):1037-40. [Content Brief]

[5]. McNamara RK, et al. Like diazepam, CL 218,872, a selective ligand for the benzodiazepine omega 1 receptor subtype, impairs place learning in the Morris water maze. Psychopharmacology (Berl). 1992;107(2-3):347-51. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5940 mL	17.9701 mL	35.9402 mL	89.8505 mL
	5 mM	0.7188 mL	3.5940 mL	7.1880 mL	17.9701 mL
	10 mM	0.3594 mL	1.7970 mL	3.5940 mL	8.9850 mL
	15 mM	0.2396 mL	1.1980 mL	2.3960 mL	5.9900 mL
	20 mM	0.1797 mL	0.8985 mL	1.7970 mL	4.4925 mL
	25 mM	0.1438 mL	0.7188 mL	1.4376 mL	3.5940 mL
	30 mM	0.1198 mL	0.5990 mL	1.1980 mL	2.9950 mL
	40 mM	0.0899 mL	0.4493 mL	0.8985 mL	2.2463 mL
	50 mM	0.0719 mL	0.3594 mL	0.7188 mL	1.7970 mL

CL 218872 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL 21887266548-69-4CL218872CL-218872GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptorratslocomotormicenxiolyticsedative and anticonvulsantInhibitorinhibitorinhibit

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CL 218872

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