2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. 4-Chlorokynurenine

4-Chlorokynurenine  (Synonyms: 4-Cl-KYN; AV-101)

Cat. No.: HY-108920 Purity: 99.94%
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4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure.

For research use only. We do not sell to patients.

4-Chlorokynurenine

4-Chlorokynurenine Chemical Structure

CAS No. : 153152-32-0

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Based on 1 publication(s) in Google Scholar

4-Chlorokynurenine Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA receptor antagonist) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure[1][2][3].

IC50 & Target[1]

NMDA Receptor

 

In Vivo

4-Chlorokynurenine (25-125 mg/kg, i.p.) inhibits depression in depressed CD-1 mice[1].
4-Chlorokynurenine (50 mg/kg, i.p., 10, 30, 120 and 360 mins after quinolinate injection) prevents hippocampal neurotoxicity in quinolinate-induced neurotoxic rats models[2].
4-Chlorokynurenine (L-4-Chlorokynurenine) (50 mg/kg, i.p., 10, 30, 120 and 360 mins after kainate) attenuates kainate-induced seizures and neuronal loss in the rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Depressed CD-1 mice[1]
Dosage: 25 and 125 mg/kg
Administration: Intraperitoneally injection
Result: Decreased immobility time in the FST.
Rapidly decreased the latency to feed in the NSF arena.
Significantly decreased immobility time.
Animal Model: Kainate-induced rats[3]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection
Result: Intraperitoneally injection, 10, 30, 120 and 360 mins after kainite Delayed seizure onset and reduced the total time spent in seizure.
Prevented KA-induced lesions in the piriform cortex.
Provided protection of hippocampal pyramidal cells in area CA1.
Molecular Weight

242.66

Formula

C10H11ClN2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC([C@@H](N)CC(C1=C(C=C(C=C1)Cl)N)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (20.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1210 mL 20.6050 mL 41.2099 mL
5 mM 0.8242 mL 4.1210 mL 8.2420 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1210 mL 20.6050 mL 41.2099 mL 103.0248 mL
5 mM 0.8242 mL 4.1210 mL 8.2420 mL 20.6050 mL
10 mM 0.4121 mL 2.0605 mL 4.1210 mL 10.3025 mL
15 mM 0.2747 mL 1.3737 mL 2.7473 mL 6.8683 mL
20 mM 0.2060 mL 1.0302 mL 2.0605 mL 5.1512 mL
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4-Chlorokynurenine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Chlorokynurenine153152-32-04-Cl-KYN AV-101AV101AV 101AV-101iGluRIonotropic glutamate receptors7-Chlorokynurenic acidNMDADepressionSeizureInhibitorinhibitorinhibit

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