2. NF-κB Apoptosis Anti-infection
  3. Keap1-Nrf2 Necroptosis SARS-CoV Virus Protease
  4. Bardoxolone (Standard)

Bardoxolone (Standard)  (Synonyms: CDDO (Standard); RTA 401 (Standard))

Cat. No.: HY-14909R
Handling Instructions Technical Support

Bardoxolone (Standard) is the analytical standard of Bardoxolone (HY-14909). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury.

For research use only. We do not sell to patients.

Bardoxolone (Standard)

Bardoxolone (Standard) Chemical Structure

CAS No. : 218600-44-3

Size Price Stock Quantity
5 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
10 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
25 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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Information

Bardoxolone (Standard) is the analytical standard of Bardoxolone (HY-14909). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

491.66

Formula

C31H41NO4
CAS No.
SMILES

CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Bardoxolone (Standard) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bardoxolone (Standard)218600-44-3CDDO (Standard)RTA 401 (Standard)Keap1-Nrf2NecroptosisSARS-CoVVirus ProteaseSARS coronaviruschronic kidney diseaseHT-29 cellsnecroptosisNrf2 activatorantioxidant systeminflammatory cytokinesapoptosisrat kidneymitochondrial damageanalgesic effectneuropathic painInhibitorinhibitorinhibit

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