2. NF-κB Apoptosis
  3. Keap1-Nrf2 Necroptosis
  4. Bardoxolone (Standard)

Bardoxolone (Standard) is the analytical standard of Bardoxolone. This product is intended for research and analytical applications. Bardoxolone (RTA 401; CDDO) is a novel nuclear regulatory factor (NRf-2) activator. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis. Bardoxolone methyl enhances the antioxidant system, modulates inflammatory cytokines and inhibits apoptosis in rat kidney, demonstrating inhibition on APAP-induced acute kidney injury (AKI) and analgesic effect. Additionally, Bardoxolone methyl decreases Paclitaxel (PAC) (HY-B0015)-induced mitochondrial damage in neuronal cells. Bardoxolone methyl is promising for the research of chemotherapy-induced neuropathic pain and chronic kidney disease.

For research use only. We do not sell to patients.

Bardoxolone (Standard) Chemical Structure

Bardoxolone (Standard) Chemical Structure

CAS No. : 218600-44-3

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Description
Molecular Weight

491.66

Formula

C31H41NO4
CAS No.
SMILES

CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Bardoxolone (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bardoxolone (Standard)218600-44-3Keap1-Nrf2Necroptosischronic kidney diseaseHT-29 cellsnecroptosisNrf2 activatorantioxidant systeminflammatory cytokinesapoptosisrat kidneymitochondrial damageanalgesic effectneuropathic painInhibitorinhibitorinhibit

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