beta Catenin Antibody (YA937)

Cat. No.: HY-P81261A: Data Sheet User Guide for Antibodies
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beta Catenin Antibody (YA937) is a non-conjugated IgG1 antibody, targeting beta Catenin, with a predicted molecular weight of 85 kDa (observed band size: 92 kDa). beta Catenin Antibody (YA937) can be used for WB experiment in human, mouse, rat background.

For research use only. We do not sell to patients.

Size	Stock	Quantity
10 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
50 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
100 μL	Get quote 4 - 5 weeks 3 - 4 weeks 3 - 4 weeks	Estimated Time of Arrival: December 31
250 μL	Get quote

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【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

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Description	beta Catenin Antibody (YA937) is a non-conjugated IgG1 antibody, targeting beta Catenin, with a predicted molecular weight of 85 kDa (observed band size: 92 kDa). beta Catenin Antibody (YA937) can be used for WB experiment in human, mouse, rat background.
Background	Beta-catenin, a pivotal player in the canonical Wnt signaling pathway, dynamically regulates cellular processes in response to Wnt ligands. In the absence of Wnt, beta-catenin participates in a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B, promoting its phosphorylation and ubiquitination, leading to subsequent degradation by the proteasome. Upon Wnt activation, beta-catenin accumulates in the nucleus, acting as a coactivator for transcription factors of the TCF/LEF family, thereby activating Wnt-responsive genes. This multifaceted protein also plays a role in cell adhesion, acting as a component of an E-cadherin:catenin adhesion complex. Beyond these functions, beta-catenin emerges as a negative regulator of centrosome cohesion and exhibits roles in insulin internalization, inhibition of anoikis, and promotion of neurogenesis. It modulates chondrocyte differentiation, positively regulates odontoblast differentiation during tooth germ formation, and interacts with various proteins, including regulators and effectors of Wnt signaling, highlighting its central role in diverse cellular processes. Beta-catenin's complex network of interactions underscores its significance in orchestrating cellular responses to intricate signaling cues, contributing to the regulation of critical cellular functions.
Gene ID	1499 [NCBI]
SwissProt ID	P35222
Synonyms	CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Molecular Weight	Predicted band size: 85 kDa; Observed band size: 92 kDa
Purity	Affinity Purified
Conjugation	Non-conjugated
Modification	Unmodified
Research Field	Signal Transduction
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Clonality	Monoclonal
Host	Mouse
Reactivity	Human, Mouse, Rat
Dilution Ratio	WB: 1/500-1/1000
Application	WB
Appearance	Liquid
Formulation	Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG1
Sensitivity	Endogenous
Immunogen	Purified recombinant human β-Catenin protein fragments expressed in E.coli.
Database	Entrez Gene: 1499 Human ; 12387 Mouse ; 84353 Rat SwissProt: P35222 Human ; Q02248 Mouse ; Q9WU82 Rat OMIM: 114500 Human
Documentation	Data Sheet (235 KB) User Guide for Antibodies (1077 KB)

beta Catenin Antibody (YA937) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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beta Catenin Antibody (YA937)

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