1. Gene
  2. T - brachyury, T-box transcription factor T Gene

T - brachyury, T-box transcription factor T Gene

Mus musculus

Also known as Lr; T1; Bra; Low; Tl2; Tl3; cou; Tbxt; me75; D17Mit170

Gene ID: 20997 | Gene type: protein coding

About T

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of gene expression. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including egg cylinder; embryo mesenchyme; future spinal cord; heart; and mesoderm. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T). [provided by Alliance of Genome Resources, Apr 2022]

T Products(1)

mRNA Protein Name
NM_009309.2 NP_033335.1 T-box transcription factor T
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7588606 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17584735 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
22164283 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16801560 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7588606 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
16835439 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15384171 MGI
acts upstream of or within bone morphogenesis IGI
IGI: Inferred from genetic interaction
11071760 MGI
involved in cardiac muscle cell myoblast differentiation IMP
IMP: Inferred from mutant phenotype
21632880 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16835439 MGI
acts upstream of or within determination of heart left/right asymmetry IMP
IMP: Inferred from mutant phenotype
10349618 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
8293872 MGI
acts upstream of or within mesoderm development IMP
IMP: Inferred from mutant phenotype
8293872 MGI
acts upstream of or within mesoderm migration involved in gastrulation IMP
IMP: Inferred from mutant phenotype
7720590 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
22164283 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22164283 MGI
acts upstream of or within neural plate morphogenesis IMP
IMP: Inferred from mutant phenotype
15384171 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
16835439 MGI
acts upstream of or within notochord development IMP
IMP: Inferred from mutant phenotype
8155581 MGI
acts upstream of or within notochord formation IMP
IMP: Inferred from mutant phenotype
7589801 MGI
acts upstream of or within penetration of zona pellucida IMP
IMP: Inferred from mutant phenotype
7883069 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16835439 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16801560 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21632880 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: Inferred from genetic interaction
11071760 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
924142 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7588606 MGI
acts upstream of or within reproductive process IMP
IMP: Inferred from mutant phenotype
924142 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
8293872 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
16835439 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
22164283 MGI
located in chromatin IMP
IMP: Inferred from mutant phenotype
21632880 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16835439 MGI
located in nucleus IDA
IDA: Inferred from direct assay
7588606 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor T

brachyury

brachyury protein

brachyury-like 2

brachyury-like 3

low ratio

protein T

T Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Tbxt P20293 Mixl1 Mus musculus Q9WUI0 22164283
Intra
Tbxt P20293 Mixl1 Mus musculus Q9WUI0 22164283
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Canis familiaris T NCBI
Felis catus T NCBI
Macaca fascicularis T NCBI
Canis lupus familiaris T NCBI
Susscrofa domestica T NCBI
Leporidae T NCBI
Rattus norvegicus T NCBI
Macaca mulatta T NCBI