Anti-Mouse/Human TYRP1 Antibody (TA99)

Cat. No.: HY-P990149: Data Sheet
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Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8+ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma.

For research use only. We do not sell to patients.

Anti-Mouse/Human TYRP1 Antibody (TA99) Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Species Reactivity

Human/Mouse

IC₅₀ & Target

TYRP1

In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse/Human TYRP1 Antibody (TA99) (450 μg, i.p., at days 4, 11,18) shows potent anti-tumor effect companied with Tyrp1 or gp100 DNA vaccine in B16 melanoma mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	B16 melanoma mice models^[1]
Dosage:	450 μg
Administration:	Intraperitoneally injection, at days 4, 11,18 companied with Tyrp1 or gp100 DNA vaccine
Result:	Revealed a significant reduction in tumor burden. Showed a 2 fold increase in the CD8+T cell response against Tyrp1455–463 in the spleens depending on Fc receptor. Localized rapidly and specifically to tumor nodules. Enhanced infiltration of the tumor by CD8+ T cells.

Gene ID

22178 [NCBI]

Accession

P07147

Molecular Weight

150 kDa

SMILES

[Anti-Mouse/Human TYRP1 Antibody (TA99)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Saenger YM, et al. Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma. Cancer Res. 2008 Dec 1;68(23):9884-91. [Content Brief]

Anti-Mouse/Human TYRP1 Antibody (TA99) Related Classifications

Cancer

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human TYRP1 Antibody (TA99)TyrosinaseTYRP1CD8+ T cellsCancerMelanomaB16Inhibitorinhibitorinhibit

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