2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5)

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) 

Cat. No.: HY-P990255 Purity: 95.00%
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Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) is an anti-mouse CXCL9/MIG IgG monoclonal antibody. Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can reduce tumor infiltration of CD8+ cytotoxic T cells (CTLs). Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can prolong the survival of transplanted hearts. Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can be used for research on immunology and cancer such as prostate cancer.

For research use only. We do not sell to patients.

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) Chemical Structure

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) Chemical Structure

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Description

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) is an anti-mouse CXCL9/MIG IgG monoclonal antibody. Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can reduce tumor infiltration of CD8+ cytotoxic T cells (CTLs). Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can prolong the survival of transplanted hearts. Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) can be used for research on immunology and cancer such as prostate cancer[1][2][3].

IC50 & Target

CXCL9/MIG
In Vivo

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) (100 μg, i.p., once every 3 days, for 2 dose) significantly reduces mXCL1-V21C/A59C induced CD8+ cytotoxic T cells (CTLs) tumor infiltration and partially reverses its anti-tumor effect in C57BL/6 mice bearing E.G7-OVA tumors or B16-F10 tumors[1].
Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) (200 μg, i.p., once every 2 days, until complete cessation of graft beating) significantly prolongs the survival time of transplanted hearts and inhibits T cell activation in male C57BL/6J mice[2].
Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) (250 μg, i.p., twice weekly, for 2 weeks) reduces the proportion of stem lines and increases the survival of side lines in male NPK mice with prostate cancer induced by Tamoxifen (HY-13757A)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 E.G7-OVA cells or 1×106 B16-F10 cells injected C57BL/6 mice (7-10 weeks)[1]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days for 2 dose
Result: Significantly reduced CTLs infiltration in tumors.
Animal Model: Male C57BL/6J mice (8-10 weeks)[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days until complete cessation of graft beating
Result: Significantly prolonged median survival time.
Significantly reduced the level of acute cellular rejection in transplants.
Significantly reduced the proportion and absolute number of CD44+CXCR3+ effector T cells (CD4+ and CD8+).
Animal Model: Tamoxifen (10.8 mg/40 g, i.g., single dose, at two months of age) induced male NPK mice[3]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), twice weekly for 2 weeks
Result: Reduced the proportion of stem lines.
Increased the survival of side lines.
Promoted the local invasiveness of stem lines.
Gene ID

17329  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCL9MIGT celltransplanted heartsCTLprostate cancerInhibitorinhibitorinhibit

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