2. Immunology/Inflammation
  3. CD28
  4. Anti-Mouse BTLA/CD272 Antibody (6A6)

Anti-Mouse BTLA/CD272 Antibody (6A6) 

Cat. No.: HY-P990298 Purity: 95.00%
COA
SDS
Technical Support

Anti-Mouse BTLA/CD272 Antibody (6A6) is an Armenian hamster-derived anti-mouse BTLA/CD272 IgG κ type antibody inhibitor. Anti-Mouse BTLA/CD272 Antibody (6A6) can be used for the researches of cancer and immunology, such as graft versus host disease (GVHD) and WF-3/Luc tumor.

For research use only. We do not sell to patients.

Anti-Mouse BTLA/CD272 Antibody (6A6)

Anti-Mouse BTLA/CD272 Antibody (6A6) Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse BTLA/CD272 Antibody (6A6) Featured Recommendations:

Anti-Mouse BTLA/CD272 Antibody (6A6) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse BTLA/CD272 Antibody (6A6) is an Armenian hamster-derived anti-mouse BTLA/CD272 IgG κ type antibody inhibitor. Anti-Mouse BTLA/CD272 Antibody (6A6) can be used for the researches of cancer and immunology, such as graft versus host disease (GVHD) and WF-3/Luc tumor[1][2][3][4].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

BTLA/CD272
In Vitro

Anti-Mouse BTLA/CD272 Antibody (6A6) (20 μg/mL, 1 h) significantly decreases percentages of BTLA+ CD19high B lymphocytes in IL-6-or IL-10-treated B lymphocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse BTLA/CD272 Antibody (6A6) Related Antibodies
In Vivo

Anti-Mouse BTLA/CD272 Antibody (6A6) (1 mg, i.p., a single dose) prevents graft versus host disease (GVHD) in allogeneic graft mice models[1].
Anti-Mouse BTLA/CD272 Antibody (6A6) (10 or 20 μg/mouse, i.p., a single dose at day 3) shows anti-tumor effect in WF-3/Luc tumor mice models[2].
Anti-Mouse BTLA/CD272 Antibody (6A6) (100 μg/mouse, i.p., twice per week for two weeks) consistently increases the frequency of both T follicular helper and T follicular regulatory cells within peyer’s patches in Btla or Tnfrsf14-deficient mice models[3].
Anti-Mouse BTLA/CD272 Antibody (6A6) (10 µg/g, i.p., a single dose) permanently prevents graft versus host disease (GVHD) in lethal mice model of GVHD[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice were grafted with allogeneic tail skin on the right flank (female, 8-12 weeks)[1]
Dosage: 1 mg
Administration: Intraperitoneally injection
Result: Reduced B cells, follicular B cells and GC B cells.
Upregulated HVEM expression on follicular and extrafollicular allogeneic Th cells.
Enhanced HVEM expression in both draining (ongoing alloreactive response) and non-draining (resting non-inflammatory response) LNs.
Animal Model: C57BL/6 J mice were challenged with WF-3/Luc tumor cells[2]
Dosage: 10 and 20 μg/mouse
Administration: Intraperitoneally injection, at day 3
Result: Suppressed tumor growth.
Displayed the highest survival rate combined with paclitaxel (Hy-B0015).
Animal Model: Btla or Tnfrsf14-deficient genetic models[3]
Dosage: 100 μg
Administration: Intraperitoneally injection, twice per week for two weeks
Result: Consistently increased the frequency of both Tfh and Tfr cells within PPs.
Animal Model: Lethal model of graft versus host disease (GVHD) [4]
Dosage: 10 µg/g
Administration: Intraperitoneally injection
Result: Eliminated weight loss, histological changes, and clinical signs of graft versus host disease.
Allowed for the expansion of preexisting donor-derived T reg cells by inhibiting T eff cell proliferation.
Increased frequency of CD4+ Foxp3+ cells.
Did not lead to global immunosuppression.
Gene ID

208154  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse BTLA/CD272 Antibody (6A6)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse BTLA/CD272 Antibody (6A6) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse BTLA/CD272 Antibody (6A6)CD28BTLACD272WF-3/LucGVHDT follicular helperT follicular regulatoryInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Mouse BTLA/CD272 Antibody (6A6)
Cat. No.:
HY-P990298
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.