2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD80/B7-1 Antibody (RM80)

Anti-Mouse CD80/B7-1 Antibody (RM80) 

Cat. No.: HY-P990127
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Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1 IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (TRM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant.

For research use only. We do not sell to patients.

Anti-Mouse CD80/B7-1 Antibody (RM80)

Anti-Mouse CD80/B7-1 Antibody (RM80) Chemical Structure

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Description

Anti-Mouse CD80/B7-1 Antibody (RM80) is an anti-mouse CD80/B7-1 IgG2a monoclonal antibody. Anti-Mouse CD80/B7-1 Antibody (RM80) can inhibit the number of tissue-resident memory (TRM) cells. Anti-Mouse CD80/B7-1 Antibody (RM80) can prolong the survival time of transplants combined with CD86 mAb. Anti-Mouse CD80/B7-1 Antibody (RM80) can be used for researches on inflammation conditions and immunology such as viral myocarditis and corneal transplant[1][2][3].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD80/B7-1
In Vivo

Anti-Mouse CD80/B7-1 Antibody (RM80) (5 mg/kg, i.p., on day 0 and day 3) significantly alleviates myocarditis in male C3H/He mice with a viral myocarditis model[1].
Anti-Mouse CD80/B7-1 Antibody (RM80) (300 μg, i.p., twice weekly, for 2 weeks) significantly inhibits the proliferation of E7 specific CD8+ T cells and the formation of tissue-resident memory (TRM) cells in C57BL/6 mice injected with Ad-R9F vaccine[2].
Anti-Mouse CD80/B7-1 Antibody (RM80) (0.1 and 0.25 mg, i.p., on day 0, 2, 4, 6, and 8 after transplantation) significantly prolongs corneal graft survival combined with CD86 mAb in male BALB/c (H-2d) mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×109 pfu CVB3 virus injected male C3H/He mice (5 weeks)[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.), on day 0 and day 3
Result: Significantly reduced the area of myocarditis to 6.00 %.
Animal Model: 1×109 IU Ad-R9F vaccine injected C57BL/6 mice (6-8 weeks)[2]
Dosage: 300 μg, combined with CD86 mAb (300 μg)
Administration: Intraperitoneal injection (i.p.), twice weekly, for 2 weeks
Result: Significantly reduced the number of E7 specific CD8+ T cells in the early stages.
Had a relatively small impact in the later stage.
Animal Model: Male BALB/c (H-2d) mice (6-8 weeks)[3]
Dosage: 0.1 and 0.25 mg
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4, 6, and 8 after transplantation
Result: Significantly prolonged the survival time of transplants.
Significantly reduced edema and infiltration.
Significantly reduced CD80+ cells.
Gene ID

12519  [NCBI]

Accession
Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD80/B7-1 Antibody (RM80)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD80/B7-1 Antibody (RM80) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD80/B7-1 Antibody (RM80)Transmembrane GlycoproteinCD80/B7-1T cellsmyocarditisCVB3corneal transplantInhibitorinhibitorinhibit

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