2. Immunology/Inflammation
  3. CD28
  4. KY-1044

KY-1044  (Synonyms: Alomfilimab; SAR 445256)

Cat. No.: HY-P99431 Purity: 99.51%
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KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

For research use only. We do not sell to patients.

CAS No. : 2489390-15-8

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Based on 1 publication(s) in Google Scholar

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Description

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

KY-1044 (Alomfilimab; SAR 445256; 0-100ng/mL; 4 hours) causes human natural killer (NK) cells expressing hICOS (5:1 effector:target cell ratio) to induce potent ADCC-mediated killing (EC50=5.6 pmol/L)[1].
KY-1044 significantly induces the luciferase signal (EC50 of 0.15 nmol/L). A similar EC50 is obtained against mouse ICOS (0.53 nmol/L), rat ICOS (0.48 nmol/L), or cynomolgus monkey ICOS (0.22 nmol/L)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KY-1044 Related Antibodies
In Vivo

KY-1044 (Alomfilimab; SAR 445256; 10 mg/kg; ip; twice a week for 3 weeks) mIgG2a (effector enable) monotherapy blocks tumor growth in lymphoma/myeloma tumor models[1].
In syngeneic mouse tumor models, KY-1044 depletes ICOShigh Treg and increases the intratumoral TEff:Treg ratio, resulting in increased secretion of IFNγ and TNFα by TEff cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-week-old wild-type female Balb/C or C57BL/6J mice with A20 cells[1]
Dosage: 200 μg (10 mg/kg)
Administration: IP; twice a week for 3 weeks starting from 6 days following tumor cell implantation
Result: Triggered an antitumor response, with more than 90% of the mice being free from measurable disease at the end of the study (day 42).
Clinical Trial
Molecular Weight

146.5 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[KY-1044]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.
Purity & Documentation
References
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KY-1044 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KY-10442489390-15-8Alomfilimab SAR 445256KY1044KY 1044SAR445256SAR 445256SAR-445256CD28HumanIgG1antibodyinducible costimulatory receptorICOSantibody-dependent cellular cytotoxicityADCCFcgRIIIaCD8+ TEff cellsFcgRimmune responseInhibitorinhibitorinhibit

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