2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD8 beta Antibody (53-5.8)

Anti-Mouse CD8 beta Antibody (53-5.8) 

Cat. No.: HY-P99128 Purity: ≥95.0%
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Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 beta IgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8+ T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology.

For research use only. We do not sell to patients.

Anti-Mouse CD8 beta Antibody (53-5.8)

Anti-Mouse CD8 beta Antibody (53-5.8) Chemical Structure

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Description

Anti-Mouse CD8 beta Antibody (53-5.8) is an anti-mouse CD8 beta IgG2a monoclonal antibody. Anti-Mouse CD8 beta Antibody (53-5.8) can deplete CD8+ T cells and enhance cytotoxicity. Anti-Mouse CD8 beta Antibody (53-5.8) can be used for research on immunology[1][2].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD8 beta
In Vitro

Anti-Mouse CD8 beta Antibody (53-5.8) (0.1-10 μg/mL, 1-2 h) enhances cytotoxicity at low concentrations (0.1 μg/mL) and significantly inhibits killing function at high concentrations (> 1 μg/mL) in OT1 CD8+ T cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD8 beta Antibody (53-5.8) Related Antibodies
In Vivo

Anti-Mouse CD8 beta Antibody (53-5.8) (10 mg/kg, i.p., once weekly, after the end of treatment) can deplete CD8+ T cells in SCID-beige mice with spontaneous HER2-driven breast cancer[1].
Anti-Mouse CD8 beta Antibody (53-5.8) (500 μg, i.p., single dose, on the second day after injecting CD45.1+ OT1 T cells) exhausts CD8+ T cells and changes them to short lived effector cells (SLEC) phenotype with enhanced cytotoxicity in C57BL/6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID-beige mice (1 month) induced with Doxycycline (HY-N0565) diet (200 mg/kg)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), once weekly after the end of treatment
Result: Decreased the number of CD8+ T cells.
Significantly increased the tumor recurrence rate compared to the control group.
Animal Model: C57BL/6 mice (5-10 weeks)[2]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), single dose, on the second day after injecting CD45.1+ OT1 T cells.
Result: Caused CD8+ T cells to exhibit the SLEC phenotype with enhanced cytotoxicity.
Gene ID

926  [NCBI]

Accession

P10966-1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD8 beta Antibody (53-5.8)]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD8 beta Antibody (53-5.8) Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD8 beta Antibody (53-5.8)Transmembrane GlycoproteinCD8 betaT cellSLECInhibitorinhibitorinhibit

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