2. GPCR/G Protein Immunology/Inflammation Anti-infection
  3. CCR HIV
  4. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) 

Cat. No.: HY-P990297 Purity: 95.00%
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Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV.

For research use only. We do not sell to patients.

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Chemical Structure

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1 Publications Citing Use of MCE Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)

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Description

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human CCL2/MCP-1 IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV[1][2][3][4][5].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Human/Mouse/Rat
IC50 & Target

CCL2/MCP-1
In Vitro

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (5 μg/mL, 16 h) significantly reduces the migration of THP-1 cells to infected enteroid-derived monolayers (EDMs)[1].
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (10 μg/mL, 24 h) significantly reduces the enhancing effect of mesenchymal stromal/stem cells (MSCs) on natural killer (NK) cell IFN-γ secretion[2].
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can inhibit the recruitment of CD8+ T cells by LILRB4 knockdown in BV2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Related Antibodies

Cell Migration Assay [1]

Cell Line: THP-1 cells
Concentration: 5 μg/mL
Incubation Time: 16 h
Result: Significantly inhibited the migration of THP-1 cells.

ELISA Assay[2]

Cell Line: NK cells, co-culture with MSCs
Concentration: 10 μg/mL
Incubation Time: 24 h
Result: Significantly reduced the level of IFN-γ.
In Vivo

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (8 mg/kg, i.p., 4 times weekly, from week 18 to week 24) significantly reduced the number of tumors combined with BLZ945 (HY-12768) in C57BL/6J mice with a Diethylnitrosamine (DEN) (HY-N7434) and Carbon tetrachloride (CCl4) (HY-Y0298) induced hepatocellular carcinoma cancer[4].
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) (100-200 μg, i.p., once every 48 h, for 12 days) significantly reduces the amount of HIV virus in TKO-BLT mice infected with HIV virus[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DEN (20 mg/kg) and CCl4 (2 μL/g) induced C57BL/6J mice[4]
Dosage: 8 mg/kg, combined with BLZ945 (200 mg/kg)
Administration: Intraperitoneal injection (i.p.), 4 times weekly from week 18 to week 24
Result: Significantly reduced the number of tumors.
Reduced M2 macrophage infiltration (CD68+ and CD206+).
Had no significant change in weight.
Animal Model: 5×104 tissue culture infectious units (TCIU) HIV virus injected TKO-BLT mice[5]
Dosage: 100 μg for first-dose, 200 μg for subsequent doses
Administration: Intraperitoneal injection (i.p.), once every 48 h for 12 days
Result: Caused only 14 % of mice to detect HIV DNA, compared to 41 % in the control group.
Did not cause virus rebound but 5 mice showed virus rebound in the control group.
Significantly increased the proportion of CCR2/5+ CD4 T cells.
Gene ID

20296  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)CCRHIVCC chemokine receptorHuman immunodeficiency virusCCL2/MCP-1IFN-γCD8IBDHCCInhibitorinhibitorinhibit

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