Anti-CD4 Antibody (OKT-4)

Cat. No.: HY-P990861 Purity: 95.00%: Data Sheet
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Anti-CD4 Antibody (OKT-4) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human CD4. Anti-CD4 Antibody (OKT-4) can deplete T cells. Anti-CD4 Antibody (OKT-4) can be used for the researches of cancer, infection and immunology, such as melanoma and adenovirus infection.

For research use only. We do not sell to patients.

Anti-CD4 Antibody (OKT-4) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Purity & Documentation
References
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Description

Isotype

Mouse IgG2b kappa

Recommend Isotype Controls

Mouse IgG2b kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD4

In Vivo

Anti-CD4 Antibody (OKT-4) (250 μg, i.p., every 2 days) depletes CD4 T cells and diminishes antitumor response of anti-PD-1 antibody in MC38/YUMM2.1 tumor C57BL/6 mice^[1].
Anti-CD4 Antibody (OKT-4) (100 μg, i.p., daily for 3 days) depletes T cells and reduces virus clearance in adenovirus-infected humanized HIS-A2/DR1 mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	MC38/YUMM2.1 tumor f C57BL/6 mice^[1]
Dosage:	250 μg
Administration:	Intraperitoneally injection, every 2 days
Result:	Depleted CD4 T cells. Diminished tumor decrease of anti-PD-1.

Animal Model:	Adenovirus-infected humanized HIS-A2/DR1 mice (hematopoietic stem cells transplantation)^[1]
Dosage:	100 μg
Administration:	Intraperitoneally injection, daily for 3 days
Result:	Depleted T cells. Abrogated the reduction of virus at day 10.

Gene ID

920 [NCBI]

Accession

P01730

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-CD4 Antibody (OKT-4)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Homet Moreno B, et al. Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells. Cancer Immunol Res. 2016 Oct;4(10):845-857. [Content Brief]

[2]. Billerbeck E, et al. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice. J Immunol. 2013 Aug 15;191(4):1753-64. [Content Brief]

Anti-CD4 Antibody (OKT-4) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CD4 Antibody (OKT-4)Transmembrane GlycoproteinCD4T cellsMelanomaAdenovirusMC38YUMM2.1Inhibitorinhibitorinhibit

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