2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) 

Cat. No.: HY-P990254 Purity: 95.00%
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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse CXCR3/CD183 IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4+ and CD8+ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for research on immunology and cancer such as pancreatic cancer.

For research use only. We do not sell to patients.

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Chemical Structure

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Chemical Structure

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Description

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse CXCR3/CD183 IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4+ and CD8+ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for research on immunology and cancer such as pancreatic cancer[1][2][3].

IC50 & Target[1][2][3]

mCXCR3

 

In Vitro

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0.001-100 μg/mL, 1 h) effectively inhibits ligand binding (CXCL10 inhibited by 60%, CXCL11 inhibited by 41%) in BaF3 cells[1].
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (0-300 μg/mL, 1 h) significantly inhibits chemotaxis induced by CXCL10 (inhibition 61%) and CXCL11 (inhibition 67%) in ConA stimulated mouse spleen cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Related Antibodies
In Vivo

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (100-500 μg, i.p., once every other day, for 2 weeks) significantly prolongs the survival time of transplants in C57BL/6 (H2d) mice with a heart transplantation model or pancreatic islet transplantation model[1].
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (500 μg, i.p., on day 14, 16, 18 and 20) reduces the number of T cells, B cells, and plasma cells in the lungs in female C57BL/6 mice injected with mRNA-LNP vaccines[2].
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) (200 μg, i.p., twice a week, for 15 days) significantly reverses the inhibitory effect of Sin3B deficiency on tumor growth and reduces CD8+ T cell infiltration in male C57BL/6J wild-type mice bearing KPC1199 tumors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (H2d) mice[1]
Dosage: 100, 200 and 500 μg
Administration: Intraperitoneal injection (i.p.), once every other day, for 2 weeks
Result: Significantly prolonged the survival time of the transplant to 16-18 days at a dose of 200 μg or 500 μg (compared to 6-7 days in the control group) for the heart transplantation model.
Extended the survival time of the pancreatic islet transplant from 12.5 days to 21 days.
Significantly reduced the infiltration of CD4+ and CD8+ T cells and protected the myocardial and vascular structures.
Animal Model: mRNA-LNP vaccines injected female C57BL/6 mice (6-8 weeks)[2]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), on day 14, 16, 18 and 20
Result: Reduced the number of CD44+Tet+CD4+/CD8+ T cells, RBD+ B cells, and IgA+ plasma cells in the lungs.
Animal Model: 1×106 KPC1199 cells injected male C57BL/6J wild-type mice[3]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 15 days
Result: Significant increased tumor size and tumor volume.
Significantly reduced CD8+ T cell infiltration.
Gene ID

2833  [NCBI]

Accession

P49682-1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR3/CD183T celltransplantspancreatic cancerKPC1199CD8CD4Inhibitorinhibitorinhibit

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Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)
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