2. PROTAC
  3. PROTAC Linkers
  4. t-Butyl acetate-PEG2-CH2COOH

t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

t-Butyl acetate-PEG2-CH2COOH

t-Butyl acetate-PEG2-CH2COOH Chemical Structure

CAS No. : 883564-93-0

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Based on 1 publication(s) in Google Scholar

t-Butyl acetate-PEG2-CH2COOH Related Antibodies

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Description

t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

t-Butyl acetate-PEG2-CH2COOH Related Antibodies
Molecular Weight

278.30

Formula

C12H22O7
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(COCCOCCOCC(OC(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (179.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5932 mL 17.9662 mL 35.9324 mL 89.8311 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL 17.9662 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL 8.9831 mL
15 mM 0.2395 mL 1.1977 mL 2.3955 mL 5.9887 mL
20 mM 0.1797 mL 0.8983 mL 1.7966 mL 4.4916 mL
25 mM 0.1437 mL 0.7186 mL 1.4373 mL 3.5932 mL
30 mM 0.1198 mL 0.5989 mL 1.1977 mL 2.9944 mL
40 mM 0.0898 mL 0.4492 mL 0.8983 mL 2.2458 mL
50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7966 mL
60 mM 0.0599 mL 0.2994 mL 0.5989 mL 1.4972 mL
80 mM 0.0449 mL 0.2246 mL 0.4492 mL 1.1229 mL
100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.8983 mL
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t-Butyl acetate-PEG2-CH2COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

t-Butyl acetate-PEG2-CH2COOH883564-93-0PROTAC LinkersInhibitorinhibitorinhibit

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