2. GPCR/G Protein
  3. GLP Receptor Arrestin
  4. CT-996

CT-996 is an orally active GLP-1RA agonist, with an EC50 of 0.49 nM. CT-996 reduces the β-arrestin recruitment and GLP-1R internalization. CT-996 suppresses postprandial blood glucose following a mixed meal tolerance test (MMTT) in mice expressing the human GLP-1 receptor and enhances glucose stimulated insulin secretion (GSIS) during an intravenous glucose challenge in obese monkeys. CT-996 can be used for the study of type 2 diabetes (T2D) and obesity.

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CT-996

CT-996 Chemical Structure

CAS No. : 2810808-95-6

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CT-996 Related Antibodies

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Description

CT-996 is an orally active GLP-1RA agonist, with an EC50 of 0.49 nM. CT-996 reduces the β-arrestin recruitment and GLP-1R internalization. CT-996 suppresses postprandial blood glucose following a mixed meal tolerance test (MMTT) in mice expressing the human GLP-1 receptor and enhances glucose stimulated insulin secretion (GSIS) during an intravenous glucose challenge in obese monkeys. CT-996 can be used for the study of type 2 diabetes (T2D) and obesity[1][2].

IC50 & Target[1]

GLP-1RA

0.49 nM (EC50)

Molecular Weight

579.59

Formula

C30H31F2N5O5
CAS No.
SMILES

C[C@@H](C[C@H](CC1)OC2=NC(COC3=C(C=C(C=C3)F)F)=NC=C2)N1CC(N(C4=C5)C[C@@H]6CCO6)=NC4=CC=C5C(O)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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CT-996 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CT-9962810808-95-6CT996CT 996GLP ReceptorArrestinGLP-1RAβ-arrestintype 2 diabetesInhibitorinhibitorinhibit

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