Anti-Rat CD80/B7-1 Antibody (3H5)

Cat. No.: HY-P990128: Data Sheet
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Anti-Rat CD80/B7-1 Antibody (3H5) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat CD80/B7-1. Anti-Rat CD80/B7-1 Antibody (3H5) blocks a costimulatory signals for T-cell activation. Anti-Rat CD80/B7-1 Antibody (3H5) can be used for the researches of cancer and immunology.

For research use only. We do not sell to patients.

Anti-Rat CD80/B7-1 Antibody (3H5) Chemical Structure

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Description

Isotype

Mouse IgG1 kappa

Recommend Isotype Controls

Mouse IgG1 kappa, Isotype Control

Species Reactivity

Rat

IC₅₀ & Target

CD80/B7-1

In Vitro

Anti-Rat CD80/B7-1 Antibody (3H5) (20 μg/mL, 4 days) inhibits TARS-1-specific proliferation in splenic T cells^[1].
Anti-Rat CD80/B7-1 Antibody (3H5) (5 μg/mL, 72 h) blocks co-stimulatory effect t of rCD80/P815 in splenic T cells^[3].
Anti-Rat CD80/B7-1 Antibody (3H5) (5 μg/mL, 72 h) inhibits stimulation of allogeneic T cells by F344-S1 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Rat CD80/B7-1 Antibody (3H5) (1 mg/rat, i.p., every other day for 2 weeks) allows tumor growth by suppressing the expansion of TARS-1-specific T-cell clone in HTLV-1 tumor mice models^[1].
Anti-Rat CD80/B7-1 Antibody (3H5) (6 mg/kg, i.v., a single dose) blocks mononuclear cell adherence in vasa recta in ischemia/reperfusion injury mice modes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HTLV-1 tumor mice models^[1]
Dosage:	1 mg/rat
Administration:	Intraperitoneally injection, every other day for 2 weeks
Result:	Tumor development consistently and had visible lung metastasis. Revealed a lymphoma-like appearance and infiltration of tumor cells in the lungs. Exhibited a markedly reduced level of proliferative and CTL response against TARS-1 cells in splenic T cells.

Animal Model:	Ischemia/reperfusion injury mice modes^[2]
Dosage:	6 mg/kg
Administration:	Intravenously injection
Result:	Showed low serum creatinine and less tubular necrosis. Had significantly more intact tubules and minimal signs of tubular damage. Reduced monocytes and T cells in the vasa recta in the ISOM.

Gene ID

12519 [NCBI]

Accession

Q00609

Molecular Weight

150 kDa

SMILES

[Anti-Rat CD80/B7-1 Antibody (3H5)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Hanabuchi S, et al. Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade. J Virol. 2000 Jan;74(1):428-35. [Content Brief]

[2]. De Greef KE, et al. Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia. Kidney Int. 2001 Oct;60(4):1415-27. [Content Brief]

[3]. Maeda K, et al. Characterization of rat CD80 and CD86 by molecular cloning and mAb. Int Immunol. 1997 Jul;9(7):993-1000. [Content Brief]

Anti-Rat CD80/B7-1 Antibody (3H5) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat CD80/B7-1 Antibody (3H5)CD28CD80B7-1T cellsTARS-1F344-S1HTLV-1Ischemia/reperfusion injuryInhibitorinhibitorinhibit

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