2. Apoptosis
  3. TNF Receptor Bcl-2 Family
  4. Anti-Mouse 4-1BB/CD137 Antibody (3H3)

Anti-Mouse 4-1BB/CD137 Antibody (3H3) 

Cat. No.: HY-P99119 Purity: 95.00%
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Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137 IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer.

For research use only. We do not sell to patients.

Anti-Mouse 4-1BB/CD137 Antibody (3H3)

Anti-Mouse 4-1BB/CD137 Antibody (3H3) Chemical Structure

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Description

Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB/CD137 IgG2a monoclonal antibody. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can effectively activate memory T cells and inhibit tumors by increasing Bcl-xL and granzyme B levels. Anti-Mouse 4-1BB/CD137 Antibody (3H3) can be used for research on cancer such as lymphoma and colon cancer[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
IC50 & Target[1]

Bcl-xL

 

In Vitro

Anti-Mouse 4-1BB/CD137 Antibody (3H3) (10 μg/mL, 2 days) enhances the expression of Bcl-xL and granzyme B on memory T cells of OT-I mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse 4-1BB/CD137 Antibody (3H3) Related Antibodies
In Vivo

Anti-Mouse 4-1BB/CD137 Antibody (3H3) (100 μg, i.p., on day 8 and 11) has significant anti-tumor activity in wild type C57BL/6 mice bearing E.G7 tumors[1].
Anti-Mouse 4-1BB/CD137 Antibody (3H3) (4 mg/kg, i.p., once every 2 days, for 3 dose) significantly inhibits tumor growth female BALB/c mice bearing CT26hEGFR tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 E.G7 cells injected wild type C57BL/6 mice (6-10 weeks)[1]
Dosage: 100 μg
Administration: Intraperitoneal injection (i.p.), on day 8 and 11
Result: Significantly inhibited tumor growth in 57% of mice.
Animal Model: 1.5×106 CT26hEGFR cells injected female BALB/c mice (6 weeks)[2]
Dosage: 4 mg/kg
Administration: Intraperitoneal injection (i.p.), once every 2 days, for 3 dose
Result: Regressed 91% of mouse tumors and induces long-term immune memory.
Significantly enlarged spleen and liver.
Caused monocyte infiltration and collagen deposition in the liver, pancreas, and lungs.
Significantly increased the levels of IFN-γ, IL-6, and TNF-α.
Gene ID

608274  [NCBI]

Accession

XP_850336.1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse 4-1BB/CD137 Antibody (3H3)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse 4-1BB/CD137 Antibody (3H3) Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse 4-1BB/CD137 Antibody (3H3)TNF ReceptorBcl-2 FamilyTumor Necrosis Factor ReceptorTNFR4-1BB/CD137Bcl-xLgranzyme BE.G7CT26Inhibitorinhibitorinhibit

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