2. Apoptosis
  3. TNF Receptor
  4. Anti-Monkey/Human CD40L/CD154 Antibody (5C8)

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) 

Cat. No.: HY-P990133 Purity: 95.00%
COA
SDS
Technical Support

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant.

For research use only. We do not sell to patients.

Anti-Monkey/Human CD40L/CD154 Antibody (5C8)

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Featured Recommendations:

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) blocks the interactionbetween CD154 and CD40. Anti-Monkey/Human CD40L/CD154 Antibody (5C8) can be used for the researches of inflammation and immunology, such as colitis and transplant[1][2].

Isotype

Mouse IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Human/Monkey
IC50 & Target

CD40L/CD154
In Vitro

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) (0.01-100 μg/mL) inhibits rhesus mixed lymphocyte reactions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Related Antibodies
In Vivo

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) (20 mg/kg, i.v., every other day for 14 days) prevents renal allograft rejection in renal allotransplant mice models[1].
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) (250 μg/mouse, i.p., twice a week for 8 weeks) prevents the onset and severity of experimental colitis in CD45RBhigh CD4+ T cell reconstitution mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Renal allotransplant mice models[1]
Dosage: 20 mg/kg
Administration: Intravenously injection, every other day beginning on the day of surgery and continuing for 14 postoperative days
Result: Experienced extended rejection-free survival and rejected between 95 and 100 days posttransplant.
Returned to normal graft function when re-treated with 7 doses of 5C8 (20 mg/kg).
Animal Model: CD45RBhigh CD4+ T cell reconstitution mice models[2]
Dosage: 250 μg/mouse
Administration: Intraperitoneally injection, twice a week for 8 weeks
Result: Did not exhibit any signs of colitis, with gradual increase of body weight and absence of diarrhea and no detectable pathological changes.
Resulted in a significant reduction of splenomegaly and of the lymphocyte infiltration in the spleen, the liver and lymphoid nodes.
Showed a low frequency of CD41 T cells, F4/801 macrophages, and CD541 cells.
Animal Model: CD45RBhigh CD4+ T cell reconstitution mice models[2]
Dosage: 250 μg/mouse
Administration: Intraperitoneally injection, twice a weekfor from 5 to 8 week
Result: Significantly diminished granulomatous inflammation, leukocyte infiltration, and epithelial hyperplasia.
Significantly decreased histological scores in the colonic sections.
Reduced CD4+ T cells and IL-2 and IFN-γ production.
decreased mRNA levels of cytokinesas well as CD40, CD40L and IL-4, IL-5, and IL-10.
Gene ID

21947  [NCBI]

Accession
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Monkey/Human CD40L/CD154 Antibody (5C8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Monkey/Human CD40L/CD154 Antibody (5C8) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Monkey/Human CD40L/CD154 Antibody (5C8)TNF ReceptorTumor Necrosis Factor ReceptorTNFRCD40LCD154InflammationImmunologyColitisCD4+ T cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Monkey/Human CD40L/CD154 Antibody (5C8)
Cat. No.:
HY-P990133
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.