2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Interleukin Related STAT
  4. Anti-Mouse IL-6 Antibody (MP5-20F3)

Anti-Mouse IL-6 Antibody (MP5-20F3) 

Cat. No.: HY-P990212 Purity: 99.20%
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Anti-Mouse IL-6 Antibody (MP5-20F3) is an anti-mouse IL-6 IgG1 monoclonal antibody. Anti-Mouse IL-6 Antibody (MP5-20F3) reshapes the tumor microenvironment by blocking IL-6. Anti-Mouse IL-6 Antibody (MP5-20F3) can inhibit the STAT3 pathway and enhance T cell infiltration. Anti-Mouse IL-6 Antibody (MP5-20F3) can be used for research on inflammation and infection conditions such as malignant pleural effusion (MPE).

For research use only. We do not sell to patients.

Anti-Mouse IL-6 Antibody (MP5-20F3) Chemical Structure

Anti-Mouse IL-6 Antibody (MP5-20F3) Chemical Structure

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Description

Anti-Mouse IL-6 Antibody (MP5-20F3) is an anti-mouse IL-6 IgG1 monoclonal antibody. Anti-Mouse IL-6 Antibody (MP5-20F3) reshapes the tumor microenvironment by blocking IL-6. Anti-Mouse IL-6 Antibody (MP5-20F3) can inhibit the STAT3 pathway and enhance T cell infiltration. Anti-Mouse IL-6 Antibody (MP5-20F3) can be used for research on inflammation and infection conditions such as malignant pleural effusion (MPE)[1][2].

IC50 & Target[1]

IL-6

 

STAT3

 

In Vivo

Anti-Mouse IL-6 Antibody (MP5-20F3) (200 μg, i.p., on day 7 and 14) significantly reduces malignant pleural effusion (MPE) volume and prolongs survival, enhance CD8+ T cell infiltration in male C57BL/6J mice bearing Lewis Lung Carcinoma (LLC) tumors[1].
Anti-Mouse IL-6 Antibody (MP5-20F3) (0.4 mg, i.p., once daily, from day 0 to day 5 or 6) reduces the level of hepcidin to normal levels in female Balb/c and C57BL/6 mice infected with parasites[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 LLC or LLC-LUC cells injected male C57BL/6J mice (6 weeks)[1]
Dosage: 200 μg, combined with anti-PD-L1 mAb (200 μg)
Administration: Intraperitoneal injection (i.p.), on day 7 and 14
Result: Significantly reduced MPE volume of mice.
Effectively prolonged survival period.
Enhanced CD8+ T cell infiltration and reduced Tregs and macrophages.
Reduced iCAFs and increased myCAFs.
Reduced PD-L1 and IL-6 expression, inhibited STAT3 activation.
Animal Model: Plasmodium yoelii XNL infected female Balb/c mice (6-8 weeks) and Plasmodium berghei NK65 infected female C57BL/6 mice (6-8 weeks)[2]
Dosage: 0.4 mg, combined with LDN193189 (3 mg/kg) (HY-12071)
Administration: Intraperitoneal injection (i.p.), once daily from day 0 to day 5 or 6
Result: Restored hepcidin to baseline levels.
Gene ID

16193  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-6 Antibody (MP5-20F3)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.20%

SDS (251 KB)

COA (232 KB) SEC-HPLC (137 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse IL-6 Antibody (MP5-20F3) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-6 Antibody (MP5-20F3)Interleukin RelatedSTATILIL-6STAT3MPEinfectionparasitesInhibitorinhibitorinhibit

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