Anti-Mouse IL-2 Antibody (S4B6-1)

Cat. No.: HY-P990796: Data Sheet
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Anti-Mouse IL-2 Antibody (S4B6-1) is an anti-mouse IL-2 IgG2a monoclonal antibody. Anti-Mouse IL-2 Antibody (S4B6-1) can reduce CD4⁺ T cells and increase Tregs. Anti-Mouse IL-2 Antibody (S4B6-1) can induce Th17 cell differentiation. Anti-Mouse IL-2 Antibody (S4B6-1) can be used for research on cancer such as melanoma. The recommend isotype control of Anti-Mouse IL-2 Antibody (S4B6-1): Rat IgG2a kappa, Isotype Control (HY-P990679).

For research use only. We do not sell to patients.

Anti-Mouse IL-2 Antibody (S4B6-1) Chemical Structure

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Anti-Mouse IL-2 Antibody (S4B6-1) Featured Recommendations:

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•Related Small Molecules:

•Related Proteins:

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target^[1]^[2]^[3]

IL-2

In Vitro

Anti-Mouse IL-2 Antibody (S4B6-1) (10 μg/mL, 72 h) can induce Th17 cell differentiation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse IL-2 Antibody (S4B6-1) (100 µg, i.p., once every 3 days) leads to accelerated tumor growth and decreased survival rate combined with IL-2 mAb (JES6-1A12) (HY-P990219) in female C57BL/6J mice bearing B16F10 tumors^[1].
Anti-Mouse IL-2 Antibody (S4B6-1) (150 μg, i.p., once every 3 days, for 2 weeks) reduces the number of central Treg cells (cTR) in C57BL/6 mice bearing B16.Flt3L tumors^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5×10⁵ B16F10 cells injected female C57BL/6J mice (8 weeks)^[1]
Dosage:	100 µg, combined with IL-2 mAb (JES6-1A12)
Administration:	Intraperitoneal injection (i.p.), once every 3 days
Result:	Significantly inhibited the expansion of natural killer (NK) cells in tumors. Accelerated tumor growth and reduced survival rate. Reduced activation phenotype of host CD4⁺ T cells (CD25⁺Foxp3^-) in tumors. Increased Tregs (CD25⁺ Foxp3⁺) in tumors.

Animal Model:	3×10⁶ B16.Flt3L cells injected C57BL/6 mice^[3]
Dosage:	150 μg
Administration:	Intraperitoneal injection (i.p.), once every 3 days, for 2 weeks
Result:	Significantly reduced cTR cells without affecting effector Treg cells (eTR). Inhibited Stat5 phosphorylation.

Gene ID

16183 [NCBI]

Accession

P04351

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

SMILES

[Anti-Mouse IL-2 Antibody (S4B6-1)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Dang N, et al. Donor Lymphocyte-Derived Natural Killer Cells Control MHC Class I-Negative Melanoma. Cancer Immunol Res. 2020 Jun;8(6):756-768. [Content Brief]

[2]. Li M, et al. Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice. Genomics Proteomics Bioinformatics. 2022 Apr;20(2):288-303. [Content Brief]

[3]. Smigiel KS, et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med. 2014 Jan 13;211(1):121-36. [Content Brief]

Anti-Mouse IL-2 Antibody (S4B6-1) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-2 Antibody (S4B6-1)Interleukin RelatedILIL-2CD4T cellsTregsB16Inhibitorinhibitorinhibit

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