2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-2 Antibody (JES6-1A12)

Anti-Mouse IL-2 Antibody (JES6-1A12) 

Cat. No.: HY-P990219 Purity: 95.00%
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Anti-Mouse IL-2 Antibody (JES6-1A12) is an anti-mouse IL-2 IgG1 monoclonal antibody. Anti-Mouse IL-2 Antibody (JES6-1A12) can inhibit Treg amplification and enhance Th1 response. Anti-Mouse IL-2 Antibody (JES6-1A12) can form a complex with IL-2 for experimentation. Anti-Mouse IL-2 Antibody (JES6-1A12) can be used for research on infection conditions such as malaria.

For research use only. We do not sell to patients.

Anti-Mouse IL-2 Antibody (JES6-1A12)

Anti-Mouse IL-2 Antibody (JES6-1A12) Chemical Structure

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Description

Anti-Mouse IL-2 Antibody (JES6-1A12) is an anti-mouse IL-2 IgG1 monoclonal antibody. Anti-Mouse IL-2 Antibody (JES6-1A12) can inhibit Treg amplification and enhance Th1 response. Anti-Mouse IL-2 Antibody (JES6-1A12) can form a complex with IL-2 for experimentation. Anti-Mouse IL-2 Antibody (JES6-1A12) can be used for research on infection conditions such as malaria[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][2]

IL-2

 

In Vitro

Anti-Mouse IL-2 Antibody (JES6-1A12) (0.2 µg/mL, 72 h) significantly inhibits the proliferation of CD4+ T cells in the chronic infection stage, but has no inhibitory effect on the proliferation in the acute infection stage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-2 Antibody (JES6-1A12) Related Antibodies

Cell Proliferation Assay[1]

Cell Line: CD4+ T cells in the spleen of mice on the 4th day after infection
Concentration: 0.2 µg/mL
Incubation Time: 72 h
Result: Inhibited the proliferation of T cells.
In Vivo

Anti-Mouse IL-2 Antibody (JES6-1A12) (1 mg/mouse/day, i.p., on day 0, 2 and 4) significantly reduces parasitic infections in female C57BL/6 mice injected with Plasmodium chabaudi AS[1].
Anti-Mouse IL-2 Antibody (JES6-1A12) (molar ratio of IL-2 to JES6-1A12 = 2:1, i.p., for 3 days) can form a complex with IL-2, significantly increasing the sensitivity of C57BL/6 mice to LPS, inducing the expansion of T cells and increasing the number of CD11b+CD14+ cells in the spleen and blood [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×106 infected red blood cells injected female C57BL/6 mice (6-8 weeks)[1]
Dosage: 1 mg/mouse/day
Administration: Intraperitoneal injection (i.p.), on day 0, 2 and 4
Result: Effectively inhibited Treg cell expansion without affecting the activation of effector CD4+ T cells or IFN-γ production.
Increased the levels of TNF-α and malaria parasite specific IgG2a antibodies and enhances protective immunity.
Significantly reduced parasitic infections by about 40 %.
Gene ID

16183  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-2 Antibody (JES6-1A12)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-2 Antibody (JES6-1A12) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-2 Antibody (JES6-1A12)Interleukin RelatedILIL-2TregTh1malariaPlasmodium chabaudi ASInhibitorinhibitorinhibit

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