Prezalumab  (Synonyms: AMG 557)

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002)^[1][2].

Human IgG2 kappa

Human IgG2 kappa, Isotype Control

Human

Prezalumab (100 nM; 48 h) inhibits the production of inflammatory cytokines such as IL-13 and IL-17A in co-culture systems of antigen-presenting cells and PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.5 kDa

1523164-68-2

Liquid

Colorless to light yellow

[Prezalumab]

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG2 kappa

• 
  Immobilized B7-H2/ICOSLG Protein, Human can bind Prezalumab. The EC₅₀ for this effect is 7.11 ng/mL.

• [1]. Dillon SR, et al. Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101). Arthritis Rheumatol. 2023 Aug;75(8):1344-1356.  [Content Brief]

  [2]. Cheng LE, et al. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 Jul;70(7):1071-1076.  [Content Brief]