JI069

Cat. No.: HY-167692 Purity: 98.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.

For research use only. We do not sell to patients.

JI069 Chemical Structure

CAS No. : 850019-35-1

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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View All Isoforms

STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

387.24

Formula

C₁₅H₁₂Cl₂N₂O₄S

CAS No.

850019-35-1

Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=C(NC(COC(CC2=C(Cl)C=CC=C2Cl)=O)=O)SC=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (322.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5824 mL	12.9119 mL	25.8238 mL
5 mM	0.5165 mL	2.5824 mL	5.1648 mL
10 mM	0.2582 mL	1.2912 mL	2.5824 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (250 KB) HNMR (254 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and collagen-induced arthritis in vivo

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5824 mL	12.9119 mL	25.8238 mL	64.5594 mL
	5 mM	0.5165 mL	2.5824 mL	5.1648 mL	12.9119 mL
	10 mM	0.2582 mL	1.2912 mL	2.5824 mL	6.4559 mL
	15 mM	0.1722 mL	0.8608 mL	1.7216 mL	4.3040 mL
	20 mM	0.1291 mL	0.6456 mL	1.2912 mL	3.2280 mL
	25 mM	0.1033 mL	0.5165 mL	1.0330 mL	2.5824 mL
	30 mM	0.0861 mL	0.4304 mL	0.8608 mL	2.1520 mL
	40 mM	0.0646 mL	0.3228 mL	0.6456 mL	1.6140 mL
	50 mM	0.0516 mL	0.2582 mL	0.5165 mL	1.2912 mL
	60 mM	0.0430 mL	0.2152 mL	0.4304 mL	1.0760 mL
	80 mM	0.0323 mL	0.1614 mL	0.3228 mL	0.8070 mL
	100 mM	0.0258 mL	0.1291 mL	0.2582 mL	0.6456 mL

JI069 Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JI069850019-35-1JI 069JI-069STATInhibitorinhibitorinhibit

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JI069

JI069 Related Antibodies

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Biological Activity

Purity & Documentation

References

Customer Review

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