2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-1a Antibody (ALF-161)

Anti-Mouse IL-1a Antibody (ALF-161) 

Cat. No.: HY-P99138 Purity: ≥95.0%
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Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for research on immune response and cancer such as breast cancer.

For research use only. We do not sell to patients.

Anti-Mouse IL-1a Antibody (ALF-161) Chemical Structure

Anti-Mouse IL-1a Antibody (ALF-161) Chemical Structure

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Description

Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8+ T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for research on immune response and cancer such as breast cancer[1][2].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
IC50 & Target[1][2]

IL-1α

 

In Vivo

Anti-Mouse IL-1a Antibody (200 μg, i.p., twice weekly, for 4 weeks) can inhibit CD8+ T cell response in C57BL/6J mice injected with adeno-associated viral-ovalbumin (AAV-OVA)[1].
Anti-Mouse IL-1a Antibody (200 µg, i.p., once every 3 days, until the end of the experiment) can reversibly transform myeloid cell expansion and improve T cell function in wild-type female C57BL/6 mice bearing AT3 tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×109 vg AAV-OVA injected C57BL/6J mice (6-8 weeks)[1]
Dosage: 200 μg, combinated with IL-1b mAb (HY-P99139) (200 μg)
Administration: Intraperitoneal injection (i.p.), twice weekly, for 4 weeks
Result: Reduced the response rate from 67 % to 33 % and lowered the frequency by about three times when used alone.
Further reduced the response rate to 19 %-20 % when combined with IL-1b mAb.
Slightly reduced anti OVA IgG2c but did not affect anti capsid antibodies.
Animal Model: 5×105 AT3 cells injected wild-type female C57BL/6 mice (8-10 weeks)[2]
Dosage: 200 μg, combinated with IL-1R mAb (HY-P99140) (200 μg)
Administration: Intraperitoneal injection (i.p.), once every 3 days until the end of the experiment
Result: Significantly reduced the expansion of neutrophils and immature CD11b+ myeloid cells in the spleen.
Prevented a decrease in T cell subpopulations, such as initial and central memory CD8+ T cells.
Reduced circulating G-CSF levels.
Effectively restored APC function and T cell response when combined with IL-1R mAb.
Gene ID

16175  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-1a Antibody (ALF-161)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-1a Antibody (ALF-161) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-1a Antibody (ALF-161)Interleukin RelatedILIL-1aCD8T cellImmunologyAT3breast cancerInhibitorinhibitorinhibit

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