2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-10 Antibody (JES5-2A5)

Anti-Mouse IL-10 Antibody (JES5-2A5) 

Cat. No.: HY-P990001 Purity: ≥95.0%
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Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for research on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM).

For research use only. We do not sell to patients.

Anti-Mouse IL-10 Antibody (JES5-2A5) Chemical Structure

Anti-Mouse IL-10 Antibody (JES5-2A5) Chemical Structure

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Description

Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for research on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM)[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
IC50 & Target[1][2][3]

IL-10

 

In Vitro

Anti-Mouse IL-10 Antibody (JES5-2A5) (24 h) restores the anti-tumor activity of IL-6 and enhances the efficacy of Mifamurtide (HY-13682) by blocking the IL-10/SOCS3 axis in MG-63, HOS and 143B cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-10 Antibody (JES5-2A5) Related Antibodies
In Vivo

Anti-Mouse IL-10 Antibody (JES5-2A5) (200 μg, i.p., twice a week, from the day 6 after immunization) can counteract the protective effect of MaR1 and increase the infiltration of IL-17+CD4+ T cells in the central nervous system (CNS) in female SJL mice with an experimental autoimmune encephalomyelitis (EAE)[1].
Anti-Mouse IL-10 Antibody (JES5-2A5) (250 μg, i.v., twice a week) significantly reduces the density of cerebral capillary occlusion in C57BL/6J mice with a Streptozotocin (STZ) (HY-13753) induced type 1 diabetes mellitus (T1DM) model[2].
Anti-Mouse IL-10 Antibody (JES5-2A5) (300 μg, i.p., single dose, 1 h after cell injection) significantly reduces tumor cell retention in the lungs combined with Mifamurtide (HY-13682) in BALB/c mice bearing K7M2 tumors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SJL mice with an EAE (8-12 weeks)[1]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), twice a week from the day 6 after immunization
Result: Weakened the protective effect of MaR1.
Increased IL-17+CD4+ T cells infiltration.
Animal Model: STZ (75 mg/kg) injected C57BL/6J mice (2-6 months)[2]
Dosage: 250 μg
Administration: Intravenous injection (i.v.), twice a week
Result: Significantly reduced the density of blocked capillaries in different brain regions.
Animal Model: 1×106 K7M2 cells injected BALB/c mice (6 weeks)[3]
Dosage: 300 μg, combined with Mifamurtide (30 μg)
Administration: Intraperitoneal injection (i.p.), single dose 1 h after cell injection
Result: Significantly reduces lung metastasis of tumor cells.
Gene ID

16153  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-10 Antibody (JES5-2A5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse IL-10 Antibody (JES5-2A5) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-10 Antibody (JES5-2A5)Interleukin RelatedILIL-10IL-6T1DMK7M2Inhibitorinhibitorinhibit

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