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  3. TNF Receptor
  4. Anti-Mouse DR5/CD262 Antibody (MD5-1)

Anti-Mouse DR5/CD262 Antibody (MD5-1) 

Cat. No.: HY-P990249
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Anti-Mouse DR5/CD262 Antibody (MD5-1) is an anti-mouse DR5/CD262 IgG monoclonal antibody. Anti-Mouse DR5/CD262 Antibody (MD5-1) can eliminate myeloid derived suppressor cells (MDSCs) and enhance T cell anti-tumor immunity. Anti-Mouse DR5/CD262 Antibody (MD5-1) can be used for research on cancer such as gastric and colon cancer.

For research use only. We do not sell to patients.

Anti-Mouse DR5/CD262 Antibody (MD5-1)

Anti-Mouse DR5/CD262 Antibody (MD5-1) Chemical Structure

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Anti-Mouse DR5/CD262 Antibody (MD5-1) Related Antibodies

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Description

Anti-Mouse DR5/CD262 Antibody (MD5-1) is an anti-mouse DR5/CD262 IgG monoclonal antibody. Anti-Mouse DR5/CD262 Antibody (MD5-1) can eliminate myeloid derived suppressor cells (MDSCs) and enhance T cell anti-tumor immunity. Anti-Mouse DR5/CD262 Antibody (MD5-1) can be used for research on cancer such as gastric and colon cancer[1][2].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

DR5/CD262
In Vivo

Anti-Mouse DR5/CD262 Antibody (MD5-1) (50 μg, i.p., once every 3 days) can deplete myeloid derived suppressor cells (MDSCs) in BALB/c mice bearing EMT-6 tumors[1].
Anti-Mouse DR5/CD262 Antibody (MD5-1) (50 μg, i.p., once every 3 days, for 3 times) significantly inhibits tumor growth in female 615 mice bearing MFC tumors or C57BL/6 mice bearing MC38 tumors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5×105 EMT-6 cells injected BALB/c mice[1]
Dosage: 50 μg
Administration: Intraperitoneal injection (i.p.), once every 3 days
Result: Reduced the number of MDSCs.
Animal Model: 1×106 MFC cells injected female 615 mice (5-7 weeks) or 5×105 MC38 cells injected female C57BL/6 mice (5-7 weeks)[2]
Dosage: 50 μg, combined with PD-L1 mAb (HY-P99145) (200 μg)
Administration: Intraperitoneal injection (i.p.), once every 3 days, for 3 times
Result: Significantly inhibited tumor volume.
Significantly prolonged the survival period of mice.
Significantly increased infiltration of CD4+ and CD8+ cells.
Significantly reduced the proportion of MDSC.
Enhanced secretion of IFN-γ and TNF-α.
Had good safety in vivo.
Gene ID

21933  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse DR5/CD262 Antibody (MD5-1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse DR5/CD262 Antibody (MD5-1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse DR5/CD262 Antibody (MD5-1)TNF ReceptorTumor Necrosis Factor ReceptorTNFRDR5/CD262MDSCsT cellCD8CD4MC38MFCInhibitorinhibitorinhibit

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