2. Immunology/Inflammation Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. CD276/B7-H3 Apoptosis STAT
  4. Anti-Mouse CD276/B7-H3 Antibody (MJ18)

Anti-Mouse CD276/B7-H3 Antibody (MJ18) 

Cat. No.: HY-P990279 Purity: 95.00%
COA
SDS
Technical Support

Anti-Mouse CD276/B7-H3 Antibody (MJ18) is a rat-derived anti-mouse CD276/B7-H3 IgG1 monoclonal antibody. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can inhibit CD276/B7-H3 and induce tumor cell apoptosis. Anti-Mouse CD276/B7-H3 Antibody (MJ18) enhances anti-tumor immune response by reducing immunosuppressive cells and promoting T cell activation. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can be used for research on cancer such as breast cancer and prostate cancer.

For research use only. We do not sell to patients.

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Chemical Structure

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Chemical Structure

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Featured Recommendations:

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Related Antibodies

Top Publications Citing Use of Products

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-Mouse CD276/B7-H3 Antibody (MJ18) is a rat-derived anti-mouse CD276/B7-H3 IgG1 monoclonal antibody. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can inhibit CD276/B7-H3 and induce tumor cell apoptosis. Anti-Mouse CD276/B7-H3 Antibody (MJ18) enhances anti-tumor immune response by reducing immunosuppressive cells and promoting T cell activation. Anti-Mouse CD276/B7-H3 Antibody (MJ18) can be used for research on cancer such as breast cancer and prostate cancer[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
IC50 & Target[1]

p-STAT3

 

In Vivo

Anti-Mouse CD276/B7-H3 Antibody (MJ18) (0.3 mg/mouse, i.p., once every other day, from day 14 to 30) significantly inhibits tumor growth and enhances T cell activity in Tgfbr1/Pten 2cKO mice induced with Tamoxifen (HY-13757A)[1].
Anti-Mouse CD276/B7-H3 Antibody (MJ18) (160 μg, i.p., twice weekly, for 2 weeks) significantly inhibits tumor growth and increases CD8+ T cell infiltration in female BALB/c mice bearing 4T1 tumors[2].
Anti-Mouse CD276/B7-H3 Antibody (MJ18) (10 mg/kg, i.p., three times a week, for 4 weeks) significantly inhibits tumor growth, synergistically increases CD8+ T cell infiltration and tumor cell apoptosis in Rosa-CD276 C57BL/6 mice induced with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) (HY-W755252)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The Squamouth Cell Carcinomas of the Head and Neck model consists of Tgfbr1/Pten 2cKO mice induced with Tamoxifen (2 mg/kg, p.o., for 5 days)[1]
Dosage: 0.3 mg/mouse
Administration: Intraperitoneal injection (i.p.), once every other day, from day 14 to 30
Result: Significantly inhibited tumor growth and reduced tumor burden.
Reduced lymph node enlargement and spleen index.
Reduced the expression of p-STAT3, CXCL1, CCL2, and B7-H3.
Reduced myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs) and enhanced T cell activity.
Animal Model: 1×107 4T1 cells injected female BALB/c mice (5-6 weeks)[2]
Dosage: 160 μg, combined with TVB-3166 (30 mg/kg, p.o., once daily) (HY-120394) and PD-L1 mAb (200 μg, i.p., twice weekly)
Administration: Intraperitoneal injection (i.p.), twice weekly for 2 weeks
Result: Inhibited tumor growth and upregulated FASN expression within tumors.
Increased CD8+ T cell infiltration and tumor cell apoptosis.
Animal Model: The bladder cancer consists of BBN induced Rosa-CD276 C57BL/6 mice[3]
Dosage: 10 mg/kg, combined with anti-PD-L1 (200 μg/mouse, on day 1, 3, 5, 7 and 14)
Administration: Intraperitoneal injection (i.p.), three times a week for 4 weeks
Result: Significantly inhibited the volume of tumors.
Increased CD8+ T cell infiltration and tumor cell apoptosis.
Gene ID

102657  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD276/B7-H3 Antibody (MJ18)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-Mouse CD276/B7-H3 Antibody (MJ18) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD276/B7-H3 Antibody (MJ18)CD276/B7-H3ApoptosisSTATB7 homolog 3 proteinCD276B7-H3breast cancerprostate cancer4T1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-Mouse CD276/B7-H3 Antibody (MJ18)
Cat. No.:
HY-P990279
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.