2. Metabolic Enzyme/Protease Apoptosis Cell Cycle/DNA Damage
  3. Indoleamine 2,3-Dioxygenase (IDO) Apoptosis SWI/SNF Complex
  4. LW106

LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma.

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LW106

LW106 Chemical Structure

CAS No. : 2116519-76-5

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LW106 Related Antibodies

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Description

LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma[1].

IC50 & Target[1]

IDO1

1.57 μM (IC50)

In Vitro

LW106 (12.5-200 μM) does not affect proliferation of three types of tumor cells (HeLa, Lewis, B16F10 cells) with different expression levels of IDO1[1].
LW106 restores the function of CD8+ T cells by blocking the activity of IDO1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LW106 Related Antibodies
In Vivo

LW106 (20-80 mg/kg, i.p., once daily for 18 days) inhibits tumor growth of Lewis lung cancer or B16F10 melanoma and its anti-tumor effect relies on T-cell immunity and host-derived IDO1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lewis and B16F10 tumors model established in 57BL6 mice, athymic nude mice or Ido1-/- mice[1]
Dosage: 20, 40 and 80 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 18 days
Result: Dose-dependently inhibited tumor growth of Lewis lung cancer or B16F10 melanoma.
Reconstructed the tumor immune microenvironment, enhanced anti-tumor immunity, and inhibited stromal cells and cancer stem cells.
Inhibited tumor proliferation, promoted apoptosis, and reduced the matrix barrier.
Inhibited the self-renewal ability of cancer stem cells.
Molecular Weight

245.24

Formula

C11H11N5O2
CAS No.
SMILES

O/N=C(N1CC2=C(C1)C=CC=C2)/C3=NON=C3N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LW106 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LW1062116519-76-5LW 106LW-106Indoleamine 2,3-Dioxygenase (IDO)ApoptosisSWI/SNF ComplexSWI/SNF Family of Chromatin-Remodelling ComplexesIDO1T cellsnon-hematopoietic stromal cellscancer stem cellsInhibitorinhibitorinhibit

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