2. Cell Cycle/DNA Damage
  3. CDK
  4. BLINK15

BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice.

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BLINK15 Chemical Structure

BLINK15 Chemical Structure

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BLINK15 Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

BLINK15 is a BBB-penetrant CDK5 inhibitor. BLINK15 lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM). BLINK15 offers anti-diabetic and neuroprotective benefits. BLINK15 lowers blood glucose, enhances cognition, and reduces neurodegeneration in T2D mice[1].

IC50 & Target

CDK9/Cyclin T

74.63 nM (IC50)

CDK1/Cly Y

35.84 nM (IC50)

CDK2/ClyA2

44.12 nM (IC50)

CDK5/p35

29.34 nM (IC50)

Cdk5/p25

12.08 nM (IC50)

In Vitro

BLINK15 (50 nM-100 nM, 24 h) lowers CDK5 activity for both complexes CDK5/p35 (IC50 = 29.34 nM) and CDK5/p25 (IC50 = 12.08 nM)[1].
BLINK15 (50 nM-100 nM, 24 h) shows declined CDK5 activity in N2A cell lines overexpressing CDK5/p35 and CDK5/p25[1].
BLINK15 (25-500 μM, 24 h) maintains cell viability above 50% at all doses in HEK293T, HepG2, and N2A cell lines[1].
BLINK15 (100-500 μM, 7 h) shows the ability to traverse the BBB and access the central nervous system[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BLINK15 Related Antibodies
In Vivo

BLINK15 (20-40 mg/kg/day, i.p., 20 days) shows rescues T2D-related symptoms in HFD-fed mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet (HFD)-fed (3-4 weeks), four-week-old male C57BL/6J mice (n=40)[1]
Dosage: 20 mg/kg/day, 40 mg/kg/day
Administration: Intraperitoneal injection (i.p.), 20 days, 3 months after HFD-fed for 3-4 weeks
Result: Demonstrated rescued symptoms caused by T2D including gaining of body weight, glucose tolerance test (GTT) and insulin tolerance test (ITT) level.
Alleviated cognitive impairment including rescued muscle strength and prevent anxiety, showing mitigated adverse effects of HFD level.
Rescued memory and spatial learning impairments in T2D mouse models with 40 mg/kg/day dosage but no effect with 20 mg/kg/day.
Significantly reduced CDK5 activity even in the presence of p25.
Molecular Weight

511.32

Formula

C24H19BrN2O6
SMILES

O[C@](C1=C(N2CC3=CC=CC=C3)C=CC(Br)=C1)(CC(C4=CC([N+]([O-])=O)=C(OC)C=C4)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BLINK15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLINK15BLINK 15BLINK-15CDKCyclin dependent kinaseCdk5inhibitorbrain-penetrantanti-diabeticneuroprotectiveneurodegenerationT2DADInhibitorinhibit

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