2. Metabolic Enzyme/Protease
  3. Liposome
  4. 9A1P9

9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t.

For research use only. We do not sell to patients.

9A1P9

9A1P9 Chemical Structure

CAS No. : 2760467-57-8

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9A1P9 Related Antibodies

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Description

9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t[1].

In Vitro

9A1P9 shows higher membrane-disruptive activity at the acidic endosomal compartment compared to that of neutral pH[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9A1P9 Related Antibodies
In Vivo

9A1P9 can efficiently deliver mRNA in mice [2].
Preparation of iPLNP[2]:
9A1P9 : Fluc mRNA = 11,622 : 1 (molar ratio).
9A1P9 : MDOA (DODAP or 5A2-SC8) : cholesterol : DMG-PEG2000 = 25 : 30 : 30 : 1 (molar ratio).
9A1P9 : DOPE : cholesterol : DMG-PEG2000 = 55 : 30 : 45 : 0.2 (molar ratio).
9A1P9 : DDAB (or DOTAP) : cholesterol : DMG-PEG2000 = 60 : 30 : 40 : 0.4 (molar ratio).
The weight ratio of 9A1P9 to RNA is 18:1 (w/w).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: female C57BL/6 mice (6-8 weeks)[2]
Dosage: 9A1P9:mRNA weight ratio was fixed at 18:1
Administration: Intravenous injection (i.v.)
Result: 9A1P9 demonstrates universal applicability to synergistically function with zwitterionic, ionizable cationic and permanently cationic helper lipids to formulate multi-component LNPs for selective organ targeting (SORT) to mediate exclusive transfection in spleen, liver or lungs in mice.
Molecular Weight

491.73

Formula

C27H58NO4P
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=P(OCCN(CCCCCCCC)CCCCCCCC)(OCCCCCCCCC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: 99.4%

SDS (393 KB)

COA (239 KB)

Handling Instructions (2659 KB)
References
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9A1P9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9A1P92760467-57-8LiposomeLNPsLipid nanoparticlesInhibitorinhibitorinhibit

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