2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) 

Cat. No.: HY-P990173 Purity: 95.00%
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Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) is a mouse-derived PD-L1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) increases IFN-γ levels in organoid-primed T cells. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) can be used for the researches of cancer, such as oral squamous cell carcinoma and mammary cancer.

For research use only. We do not sell to patients.

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) Chemical Structure

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) Chemical Structure

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Description

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) is a mouse-derived PD-L1 IgG1 κ type antibody inhibitor. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) increases IFN-γ levels in organoid-primed T cells. Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) can be used for the researches of cancer, such as oral squamous cell carcinoma and mammary cancer[1][2].

Isotype

Mouse IgG1 kappa
Recommend Isotype Controls
IC50 & Target

PD-L1
In Vitro

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) (10 μg/mL, 2 days) increases IFN-γ levels in organoid-primed T cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) Related Antibodies
In Vivo

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) (200 μg/rat, submucosally injection, twice a week at 16-20 week) alleviates mucosal lesions and the pathological impairment in 4-Nitroquinoline N-oxide (4NQO)‑induced oral squamous cell carcinoma (OSCC) rats models[1].
Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) (10 mg/kg, i.p., weekly for 6 weeks) significantly suppresses tumor growth in Nitroso-N-methylurea (NMU)-induced mammary tumor rats models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-Nitroquinoline N-oxide (4NQO) (HY-33354)‑induced oral squamous cell carcinoma (OSCC) rats models (SD, male, 16 weeks)[1]
Dosage: 200 μg/rat
Administration: Submucosally injection, twice a week at 16-20 week
Result: Alleviated mucosal lesions and the pathological impairment of OSCC.
Decreased CD8+T and CD11b cells.
Animal Model: Nitroso-N-methylurea (NMU) (HY-34758)-induced mammary tumor rats models (SD, female, 3-4 weeks)[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection, weekly for 6 weeks
Result: Significantly suppressed tumor growth.
Gene ID

60533  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat/Human PD-L1 Antibody (368A.4H1)PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1IFN-γ4NQOOSCCNMUCancerInhibitorinhibitorinhibit

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