Antibacterial agent 292 

Antibacterial agent 292 is a 3-pyrazolylindole derivative. Antibacterial agent 292 is an anti-bacterial agent. Antibacterial agent 292 shows potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC₅₀ values of 2.54 and 3.49 μg/mL. Antibacterial agent 292 can suppress biofilm formation, bacterial motility, and extracellular polysaccharide production, induce morphological alterations and promote ROS accumulation, ultimately triggers bacterial apoptosis. Antibacterial agent 292 down-regulates the expression of genes associated with the type VI secretion system (T6SS). Antibacterial agent 292 can be used in rice bacterial blight and citrus canker^[1].

Antibacterial agent 292 (Compound P16) (3.125-25 μg/mL) inhibits growth of Xoo and Xac cells^[1].
Antibacterial agent 292 (3.125-12.5 μg/mL) increases ROS accumulation and induces apoptosis in Xoo and Xac cells^[1].
Antibacterial agent 292 (3.125-50 μg/mL) inhibits biofilm formation, exopolysaccharide content and motility in Xoo and Xac cells^[1].
Antibacterial agent 292 reduces the expressions of vgrG, hcp, and clpV in T6SS in Xoo cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

448.95

C₂₄H₂₅ClN₆O

3065015-86-0

ClC1=CC=C(CN(CC2)CCN2CC(NC3=CC(C4=CNC5=C4C=CC=C5)=NN3)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu G, et al. Design, Synthesis, and Antibacterial Activity Evaluation and Mechanism of 1-H-Indole-3-pyrazolamide Derivatives Containing Piperazine. J Agric Food Chem. 2025 Sep 24;73(38):24404-24415.  [Content Brief]