Anti-Mouse OX40/CD134 Antibody (OX-86)

Cat. No.: HY-P990115: Data Sheet
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Anti-Mouse OX40/CD134 Antibody (OX-86) is an anti-mouse OX40/CD134 IgG1 monoclonal antibody. Anti-Mouse OX40/CD134 Antibody (OX-86) can enhance the anti-tumor function of CD8⁺ T cells. Anti-Mouse OX40/CD134 Antibody (OX-86) can reverse immune suppression, enhance antigen presentation and T cell activation. Anti-Mouse OX40/CD134 Antibody (OX-86) can be used for research on cancer such as papilloma and leukemia.

For research use only. We do not sell to patients.

Anti-Mouse OX40/CD134 Antibody (OX-86) Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

OX40/CD134

In Vitro

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg/mL, 5-7 days) upregulates the activation markers of DCs (CD40 and CD86) and reduces the expression of PD-L1 in SB28-OVA and EG7-OVA cells^[3].
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 µg/mL, 1 h) significantly enhances tumor cell apoptosis induced by tumor infiltrating lymphocytes (TILs)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg, i.p., twice a week) has limited inhibitory effect on tumor growth in female C57BL/6 mice bearing TC-1 tumors^[1].
Anti-Mouse OX40/CD134 Antibody (OX-86) (10 mg/kg, i.p., once a week, for 2 dose) significantly inhibits tumor growth combined with PEG-MTAP in DBA/2 mice bearing L1210 tumors^[2].
Anti-Mouse OX40/CD134 Antibody (OX-86) (200 µg, i.p., on day 4, 7 and 10) significantly inhibits tumor growth in female C57BL/6 mice bearing SB28-OVA or EG7-OVA tumors^[3].
Anti-Mouse OX40/CD134 Antibody (OX-86) (100 µg, i.p., twice a week, for 2 weeks) delays tumor growth and enhances CD8⁺ T cell function in C57BL/6 mice bearing MC38 tumors^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1×10⁵ TC-1 cells injected female C57BL/6 mice (6-8 weeks)^[1]
Dosage:	100 µg
Administration:	Intraperitoneal injection (i.p.), twice a week
Result:	Had a weak inhibitory effect on tumor growth.

Animal Model:	5×10⁴ L1210 cells injected DBA/2 mice (6-8 weeks)^[2]
Dosage:	10 mg/kg, combined with PEG-MTAP (50 mg/kg, s.c., 3 times a week, for 5 dose)
Administration:	Intraperitoneal injection (i.p.), once a week, for 2 dose
Result:	Significantly inhibited tumor volume.

Animal Model:	1600 SB28-OVA cells or 25000 EG7-OVA cells injected female C57BL/6 mice (6-8 weeks)^[3]
Dosage:	200 µg
Administration:	Intraperitoneal injection (i.p.), on day 4, 7 and 10
Result:	Extended the survival period of mice (median survival period extended from 26 days to 31 days). Reduced the proportion of Tregs and increased the number of memory T cells.

Animal Model:	C57BL/6 mice bearing MC38/gp100 tumors^[4]
Dosage:	100 µg
Administration:	Intraperitoneal injection (i.p.), twice a week, for 2 weeks
Result:	Delayed tumor growth. Enhanced CD8⁺ T cell function.

Gene ID

22163 [NCBI]

Accession

P47741

Molecular Weight

150 kDa

SMILES

[Anti-Mouse OX40/CD134 Antibody (OX-86)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Sun Z, et al. Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants. Vaccines (Basel). 2025 Jan 9;13(1):49. [Content Brief]

[2]. Gjuka D, et al. Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance. Cancer Cell. 2023 Oct 9;41(10):1774-1787.e9. [Content Brief]

[3]. Badillo-Godinez O, et al. Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment. J Immunother Cancer. 2025 May 19;13(5):e011548. [Content Brief]

[4]. Peng W, et al. Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma. Clin Cancer Res. 2019 Nov 1;25(21):6406-6416. [Content Brief]

Anti-Mouse OX40/CD134 Antibody (OX-86) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse OX40/CD134 Antibody (OX-86)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorOX40/CD134TC-1L1210CD8T cellsSB28EG7MC38Inhibitorinhibitorinhibit

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