Anti-Mouse CD90.2 Antibody (30H12)

Cat. No.: HY-P99131 Purity: 95.00%: Data Sheet
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Anti-Mouse CD90.2 Antibody (30H12) is an anti-mouse CD90.2 IgG2b antibody inhibitor derived from host Rat. Anti-Mouse CD90.2 Antibody (30H12) can deplete innate lymphoid cells (ILC) and T cells. Anti-Mouse CD90.2 Antibody (30H12) can be used for the researches of infection, inflammation and immunology, such as Yersinia enterocolitica infection and airway inflammation.

For research use only. We do not sell to patients.

Anti-Mouse CD90.2 Antibody (30H12) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Isotype

Rat IgG2b kappa

Recommend Isotype Controls

Rat IgG2b kappa, Isotype Control

Species Reactivity

Human/Mouse

In Vivo

Anti-Mouse CD90.2 Antibody (30H12) (100 μg/mouse, i.p., at days -4, -1, 2, 5) depletes innate lymphoid cells (ILC) and reduces survival rate in Rag1^−/− mice with Yersinia enterocolitica infection^[1].
Anti-Mouse CD90.2 Antibody (30H12) (500 μg/mouse, i.p., every other day for 4 times) depletes innate lymphoid 2 cells (ILC2) and reduces airway inflammation and hyperresponsiveness in ozone-induced mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rag1^−/− mice with Yersinia enterocolitica infection^[1]
Dosage:	500 μg/mouse
Administration:	Intraperitoneally injection, at days -4, -1, 2, 5
Result:	Depleted ILC and most NK cells in the small intestinal lamina propria. Had a decreased survival rate and rapid weight loss. Increased bacterial burden in the ileum, spleen and liver.

Animal Model:	Ozone-induced mice^[2]
Dosage:	100 μg/mouse
Administration:	Intraperitoneally injection, every other day for 4 times
Result:	Depleted ILC2 and T cells. Reduced total cell count and neutrophil and abolished eosinophils in the BAL fluid. Abolished IL-5 release in the BAL.

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD90.2 Antibody (30H12)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Seo GY, et al. LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection. Cell Host Microbe. 2018 Aug 8;24(2):249-260.e4. [Content Brief]

[2]. Yang Q, et al. Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 2016 Feb;137(2):571-8. [Content Brief]

Anti-Mouse CD90.2 Antibody (30H12) Related Classifications

Inflammation/Immunology Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD90.2 Antibody (30H12)Transmembrane GlycoproteinCD90.2Lymphoid cellsT cellsYersinia enterocoliticaIL-5Inhibitorinhibitorinhibit

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