2. Cell Cycle/DNA Damage Epigenetics Cytoskeleton
  3. HDAC Microtubule/Tubulin
  4. T-518

T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy.

For research use only. We do not sell to patients.

T-518 Chemical Structure

T-518 Chemical Structure

CAS No. : 2276680-91-0

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10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

T-518 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy[1][2].

IC50 & Target

hHDAC6

36 nM (IC50)

In Vitro

T-518 inhibits human HDAC6 enzyme activity with IC50 of 36 nM (without pre-incubation) and 4.6 nM (after 60 min pre-incubation), but does not obviously inhibit HDAC1, 4, or 7[1].
T-518 (0.1-10 μM, 24 h) elevates tubulin acetylation significantly and dose-dependently in mouse primary neural cultures[1].
T-518 (3-30 μM, 24 h) does not increase histone H3 acetylation in mouse primary neural cultures [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

T-518 Related Antibodies
In Vivo

T-518 (0.3-300 mg/kg, p.o., one single dose) increases tubulin acetylation dose-dependently in hippocampi 4 h after administration in C57BL/6J mice[1].
T-518 (300 mg/kg, p.o., one single dose) significantly elevates tubulin acetylation in WT mice but no effect on HDAC6 KO mice, suggesting the effect is dependent on HDAC6 inhibition[1].
T-518 (1-3 mg/kg, p.o., daily for 2 weeks) improves axonal transport in P301S tau Tg mice[1].
T-518 (1-3 mg/kg, p.o., daily for 3 months) decreases aging-dependent accumulation of tau in the FA fraction in mouse hippocampus without affecting the RAB-soluble and RIPA-soluble fractions[1].
T-518 (1-3 mg/kg, p.o., 2 w) ameliorates the novel object recognition deficit observed in vehicle-treated Tg mice compared to WT mice dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

495.35

Formula

C19H16F7N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(F)(F)C(F)(F)F)N[C@H]1[C@H](N2CC3=NC=C(C4=NN=C(C(F)F)O4)C=C3C2=O)CCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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T-518 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-5182276680-91-0T518T 518HDACMicrotubule/TubulinHistone deacetylasesAlzheimer’s diseasetauopathyHDAC6neurodegenerativeInhibitorinhibitorinhibit

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