2. Immunology/Inflammation
  3. CD3
  4. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 

Cat. No.: HY-P99146 Purity: ≥95.0%
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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for research on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer.

For research use only. We do not sell to patients.

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Chemical Structure

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Chemical Structure

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Description

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for research on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer[1][2][3].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
In Vitro

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, 2 days) significantly reduces the number of γδ T cells in spleen and lymph nodes of mice[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL, 48 h) enhances IFN-γ production in γδ T cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Related Antibodies

ELISA Assay[3]

Cell Line: γδ T cells
Concentration: 5 μg/mL, co-incubation with PSK (100 μg/mL)
Incubation Time: 48 h
Result: Significantly increased the level of IFN-γ to 12823 pg/mL.
In Vivo

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (250 μg, i.p., on day 0, 3, 6, 9 and 12) exhausts γδ T cells in the central nervous system (CNS) in TCRβ-/- mice infected with JHM virus[1].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., on day 0, 5 and 10) significantly reduces the incidence rate of arthritis in male B10.RIII mice with an IL-23 induced arthritis[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., twice weekly, for 4 weeks) can deplete γδ T cells in neu-transgenic mice bearing MMC tumors[3].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg, i.p., single dose, on day -3) significantly inhibits T cell infiltration in female BDF1 mice with a graft-versus-host disease (GVHD) model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1000 PFU JHM virus injected TCRβ-/- mice[1]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 3, 6, 9 and 12
Result: Significantly reduced the number of gamma delta T cells.
Reduced the degree of demyelination by 73 %.
Significantly improved clinical scores without limb paralysis.
Animal Model: IL-23 induced male B10.RIII mice (12-14 weeks)[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 5 and 10
Result: Significantly reduced the incidence rate of arthritis to 46.15 % (80 % in the control group) and reduced the disease severity score.
Reduced the accumulation of neutrophils in the blood, spleen, bone marrow, and joints.
Significantly reduced serum IL-17A levels and increased IL-27 p28 levels.
Reduced synovial hyperplasia in joints.
Animal Model: 1×106 MMC cells injected neu-transgenic mice[3]
Dosage: 200 μg, combined with PSK (100 mg/kg)
Administration: Intraperitoneal injection (i.p.), twice weekly for 4 weeks
Result: Significantly weakened the anti-tumor effect of PSK and increased tumor volume.
Animal Model: 2×108 splenocytes of B6 mice injected female BDF1 mice (8-10 weeks)[4]
Dosage: 500 µg
Administration: Intraperitoneal injection (i.p.), single dose, on day -3
Result: Significantly inhibited the infiltration of donor derived T cells into intestinal epithelium to 32 %.
Significantly reduced the mitotic index (MI) and apoptosis index (AI) of crypt cells.
Significantly reduced intestinal lesions.
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)CD3Cluster of differentiation 3TCR gamma/deltaT cellsarthritisJHMMMCtransplantsGVHDInhibitorinhibitorinhibit

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