2. Apoptosis
  3. Apoptosis
  4. Neihulizumab

Neihulizumab  (Synonyms: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab))

Cat. No.: HY-P99378 Purity: ≥99.0%
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Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research.

For research use only. We do not sell to patients.

CAS No. : 2158362-38-8

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Based on 1 publication(s) in Google Scholar

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Description

Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized

In Vitro

Neihulizumab is a monoclonal antibody against P-selectin glycoprotein ligand-1 (PSGL-1). Neihulizumab binds to human PSGL-1, thereby preferentially inducing apoptosis in late stage activated T cells. At sites of inflammation, the endothelium of blood vessels expresses P-selectin, and activated T cells bind to these sites and migrate through the expression of PSGL-1. In that manner, Neihulizumab is thought to target activated T cells and inhibit trafficking to sites of inflamed tissue[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neihulizumab Related Antibodies
Clinical Trial
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.72 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Neihulizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized CD162/PSGL-1 Protein, Human (HEK293, His, HY-P77163) can bind Neihulizumab. The EC50 for this effect is 2.298 ng/mL.
Purity & Documentation
References
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Neihulizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neihulizumab2158362-38-8ALTB-168Anti-PSGL1/CD162 Reference Antibody (neihulizumab)ALTB168ALTB 168Apoptosishumanised monoclonal antibodyCD162PSGL-1SR-aGVHDpsoriasispsoriatic arthritis and ulcerative colitisT-cellsInhibitorinhibitorinhibit

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