Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) 

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) is an agonistic rat-derived IgG1 κ type antibody, targeting to mouse 4-1BB/CD137. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can stimulate 4-1BB signaling and induce T cell mediated antitumor immunity. Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) can be used for the researches of cancer, infection, immunology and neurological disease, such as glioblastoma and retrovirus infection^[1][2].

Rat IgG1 kappa

Rat IgG1 kappa, Isotype Control

Mouse

4-1BB/CD137

Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (200 μg, i.p., every 3 days from day 9) improves glioblastoma tumor infiltrating lymphocytes function and prolongs survival companied with anti-PD-1 (HY-P99144) in CT2A tumor mice^[1].
Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3) (100 μg, i.p., every other day from day 4 after infection) slightly enhances the numbers of virus-specific CD4⁺ T cells and greatly augments GzmB expression in Friend retrovirus infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

21942  [NCBI]

P20334

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse 4-1BB/CD137 Antibody (LOB12.3)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Woroniecka KI, et al. 4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers. Clin Cancer Res. 2020 Mar 15;26(6):1349-1358.  [Content Brief]

  [2]. Manzke N, et al. CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells. J Virol. 2013 Jun;87(11):6306-13.  [Content Brief]