2. Membrane Transporter/Ion Channel
  3. VDAC
  4. SW016789

SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 ( T2DM ) β-cell dysfunction.

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SW016789 Chemical Structure

SW016789 Chemical Structure

CAS No. : 292613-04-8

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SW016789 Related Antibodies

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Description

SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly[1]. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 ( T2DM ) β-cell dysfunction[2].

In Vitro

SW016789 (5 μM; 0-24 h) can enhance insulin secretion stimulated by glucose within a short period of time (1-2 h), but results in loss of β cell function after longer exposure (4–24 h) in MIN6 cells[2].
SW016789 (5 μM; 24-72 h) does not affect beta cell viability or apoptosis in MIN6 cells[2].
SW016789 (5 μM; 24h) enhances nutrient-stimulated Ca2+ influx to elicit hypersecretion, VDAC1 is a pharmacological target for insulin hypersecretion in mouse MIN6 cells and human EndoC-βH1 cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SW016789 Related Antibodies

Cell Viability Assay[2]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Did not alter relative amounts of live cells, dead cells, or the live/dead cell ratio.

Western Blot Analysis[1]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h
Result: Caused loss of function alone or in combination with eeyarestatin I (ES1) (HY-110078).

Western Blot Analysis[1]

Cell Line: Mouse MIN6; human EndoC-βH1
Concentration: 5 μM
Incubation Time: 1 h, 2 h, 4 h, 6 h, 24 h
Result: Induced the immediate-early response and did not robustly engage canonical ER stress pathways.
Molecular Weight

349.45

Formula

C20H19N3OS
CAS No.
SMILES

N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SW016789 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW016789292613-04-8SW 016789SW-016789VDACVoltage-dependent anion channelER stressER-associated degradationcongenital hyperinsulinismdiabeteshypersecretioninsulin secretionpancreatic isletstarget identificationtranscriptomicsβ cellsInhibitorinhibitorinhibit

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