2. Membrane Transporter/Ion Channel
  3. VDAC
  4. SW016789

SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction.

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SW016789

SW016789 Chemical Structure

CAS No. : 292613-04-8

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Based on 1 publication(s) in Google Scholar

SW016789 Related Antibodies

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Description

SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction[1][2].

In Vitro

SW016789 (5 μM; 0-24 h) can enhance insulin secretion stimulated by glucose within a short period of time (1-2 h), but results in loss of β cell function after longer exposure (4-24 h) in MIN6 cells[2].
SW016789 (5 μM; 24-72 h) does not affect beta cell viability or apoptosis in MIN6 cells[2].
SW016789 (5 μM; 24h) enhances nutrient-stimulated Ca2+ influx to elicit hypersecretion, VDAC1 is a pharmacological target for insulin hypersecretion in mouse MIN6 cells and human EndoC-βH1 cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SW016789 Related Antibodies

Cell Viability Assay[2]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Did not alter relative amounts of live cells, dead cells, or the live/dead cell ratio.

Western Blot Analysis[1]

Cell Line: MIN6
Concentration: 5 μM
Incubation Time: 24 h
Result: Caused loss of function alone or in combination with eeyarestatin I (ES1) (HY-110078).

Western Blot Analysis[1]

Cell Line: Mouse MIN6; human EndoC-βH1
Concentration: 5 μM
Incubation Time: 1 h, 2 h, 4 h, 6 h, 24 h
Result: Induced the immediate-early response and did not robustly engage canonical ER stress pathways.
Molecular Weight

349.45

Formula

C20H19N3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8616 mL 14.3082 mL 28.6164 mL
5 mM 0.5723 mL 2.8616 mL 5.7233 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8616 mL 14.3082 mL 28.6164 mL 71.5410 mL
5 mM 0.5723 mL 2.8616 mL 5.7233 mL 14.3082 mL
10 mM 0.2862 mL 1.4308 mL 2.8616 mL 7.1541 mL
15 mM 0.1908 mL 0.9539 mL 1.9078 mL 4.7694 mL
20 mM 0.1431 mL 0.7154 mL 1.4308 mL 3.5770 mL
25 mM 0.1145 mL 0.5723 mL 1.1447 mL 2.8616 mL
30 mM 0.0954 mL 0.4769 mL 0.9539 mL 2.3847 mL
40 mM 0.0715 mL 0.3577 mL 0.7154 mL 1.7885 mL
50 mM 0.0572 mL 0.2862 mL 0.5723 mL 1.4308 mL
60 mM 0.0477 mL 0.2385 mL 0.4769 mL 1.1923 mL
80 mM 0.0358 mL 0.1789 mL 0.3577 mL 0.8943 mL
100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7154 mL
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SW016789 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW016789292613-04-8SW 016789SW-016789VDACVoltage-dependent anion channelER stressER-associated degradationcongenital hyperinsulinismdiabeteshypersecretioninsulin secretionpancreatic isletstarget identificationtranscriptomicsβ cellsInhibitorinhibitorinhibit

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