2. Disease Areas
  3. Metabolic or Endocrine Disease
  4. Glucose Metabolism

Glucose Metabolism

Glucose metabolism is a vital biochemical process in cardiomyocytes that involves the uptake, utilization, and storage of glucose to generate energy, primarily through glycolysis, glycogen synthesis, glycogenolysis, and the pentose phosphate pathway. During myocardial ischemia, reduced oxygen supply forces cardiomyocytes to rely on anaerobic glycolysis for ATP production, leading to impaired function. Upon reperfusion, restored oxygen and nutrient delivery facilitates the recovery of normal glucose metabolism, which is essential for energy replenishment. However, excessive glucose during reperfusion can cause metabolite accumulation and inadequate energy supply, contributing to exacerbated myocardial ischemia-reperfusion injury. This complex interplay of metabolic pathways ensures cellular energy homeostasis and functional recovery after ischemic events.

 

Glucose Metabolism (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-17386
    Rosiglitazone 122320-73-4 99.94%
    Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone is an TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.
    Rosiglitazone