2. Immunology/Inflammation
  3. CTLA-4
  4. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 

Cat. No.: HY-P990256 Purity: 95.00%
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Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon.

For research use only. We do not sell to patients.

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) Chemical Structure

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Description

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon[1][2].

IC50 & Target

CTLA-4/CD152
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) Related Antibodies
In Vivo

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (500 μg at 1 day before injection, 250 μg at day 2 and 5, i.p.) increases regulatory T cells, T follicular helper and T follicular regulatory cells in NP-2W1S-GFP transferred mice[1].
Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (15 mg/kg, i.p., a single dose) shows potent anti-tumor effect in colon 26 tumor mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human CD2 IL-4 reporter C57BL/6 mice were injected NP-2W1S-GFP in alum[1]
Dosage: 500 μg at 1 day before injection, 250 μg at day 2 and 5
Administration: Intraperitoneally injection
Result: Caused the expansion of total regulatory T cells, T follicular helper and T follicular regulatory cells.
Induced significant expansion of tetramer-binding PD1+Bcl6+ Tfh, PD1+Bcl6- activated T cells and PD1-Bcl6- cells.
Decreased numbers of tetramer-binding T follicular regulatory cells.
Animal Model: Colon 26 tumor mice models[2]
Dosage: 15 mg/kg
Administration: Intraperitoneally injection, a single dose
Result: Showed tumor regressions in 100% of animals.
Resulted in depletion of tumor-associated T cells and a shift in the ratio of CD8+ to regulatory T cells cells.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152CancerImmunologyColonRegulatory T cellsInhibitorinhibitorinhibit

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