2. NF-κB Immunology/Inflammation
  3. NF-κB Nuclear Factor of activated T Cells (NFAT)
  4. Peptide P60

Peptide P60  (Synonyms: FOXP3 inhibitor P60)

Cat. No.: HY-P1684 Purity: 98.39%
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Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors NF-κB and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Peptide P60 Chemical Structure

Peptide P60 Chemical Structure

CAS No. : 1319725-20-6

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Based on 1 publication(s) in Google Scholar

Peptide P60 Related Antibodies

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Description

Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors NF-κB and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.[1]

Molecular Weight

1994.34

Formula

C95H132N24O20S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-Met
Sequence Shortening

RDFQSFRKMWPFFAM
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (25.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5014 mL 2.5071 mL 5.0142 mL
5 mM 0.1003 mL 0.5014 mL 1.0028 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5014 mL 2.5071 mL 5.0142 mL 12.5355 mL
5 mM 0.1003 mL 0.5014 mL 1.0028 mL 2.5071 mL
10 mM 0.0501 mL 0.2507 mL 0.5014 mL 1.2535 mL
15 mM 0.0334 mL 0.1671 mL 0.3343 mL 0.8357 mL
20 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
25 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5014 mL
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Peptide P60 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peptide P601319725-20-6FOXP3 inhibitor P60Peptide P 60Peptide P-60NF-κBNuclear Factor of activated T Cells (NFAT)Nuclear factor-κBNuclear factor-kappaBantitumor immunotherapiesantiviral immunotherapiesscurfy micelymphoproliferative autoimmune syndromeTregInhibitorinhibitorinhibit

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