2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. N3-PEG3-VC-PAB-MMAF

N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate containing the ADC linker N3-PEG3-VC-PAB and the tubulin inhibitor MMAF. N3-PEG3-VC-PAB-MMAF is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

N3-PEG3-VC-PAB-MMAF Chemical Structure

N3-PEG3-VC-PAB-MMAF Chemical Structure

CAS No. : 2757277-32-8

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Based on 1 publication(s) in Google Scholar

N3-PEG3-VC-PAB-MMAF Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N3-PEG3-VC-PAB-MMAF

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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  • Customer Review

Description

N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate containing the ADC linker N3-PEG3-VC-PAB and the tubulin inhibitor MMAF[1]. N3-PEG3-VC-PAB-MMAF is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N3-PEG3-VC-PAB-MMAF Related Antibodies
Molecular Weight

1352.62

Formula

C66H105N13O17
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(COCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (73.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7393 mL 3.6965 mL 7.3931 mL
5 mM 0.1479 mL 0.7393 mL 1.4786 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7393 mL 3.6965 mL 7.3931 mL 18.4826 mL
5 mM 0.1479 mL 0.7393 mL 1.4786 mL 3.6965 mL
10 mM 0.0739 mL 0.3697 mL 0.7393 mL 1.8483 mL
15 mM 0.0493 mL 0.2464 mL 0.4929 mL 1.2322 mL
20 mM 0.0370 mL 0.1848 mL 0.3697 mL 0.9241 mL
25 mM 0.0296 mL 0.1479 mL 0.2957 mL 0.7393 mL
30 mM 0.0246 mL 0.1232 mL 0.2464 mL 0.6161 mL
40 mM 0.0185 mL 0.0924 mL 0.1848 mL 0.4621 mL
50 mM 0.0148 mL 0.0739 mL 0.1479 mL 0.3697 mL
60 mM 0.0123 mL 0.0616 mL 0.1232 mL 0.3080 mL
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N3-PEG3-VC-PAB-MMAF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N3-PEG3-VC-PAB-MMAF2757277-32-8Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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