2. Immunology/Inflammation
  3. CD28
  4. Tiragolumab

Tiragolumab  (Synonyms: MTIG-7192A; RG-6058)

Cat. No.: HY-P9986 Purity: 99.04%
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Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma.

For research use only. We do not sell to patients.

CAS No. : 1918185-84-8

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Based on 1 publication(s) in Google Scholar

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Tiragolumab Related Antibodies

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Description

Tiragolumab is an immune checkpoint inhibitor binding to the T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab in combination with Atezolizumab (HY-P9904) and Bevacizumab (HY-P9906) has benefit in unresectable hepatocellular carcinoma. Tiragolumab can be used to study non-small cell lung cancer (NSCLC) and melanoma[1][2][3][4].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

TIGIT
In Vivo

Tiragolumab (10 mg/kg; i.p.) shows no inhibitory effect on the growth of A375 tumor xenografts alone, and combined therapy with Atezolizumab (HY-P9904) shows no synergistic effect in NSG mice co-implanted with primary human T cells and A375 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Gene ID

201633  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

148.66 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tiragolumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Tiragolumab has a significant ADCP effect on CHO-K1/TIGIT cells in a dose-dependent manner.The EC50 for this effect is 189.43 ng/mL.
Purity & Documentation
References
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Tiragolumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiragolumab1918185-84-8MTIG-7192A RG-6058RG6058RG 6058RG-6058CD28immune checkpointT-cell immunoglobulinITIM domainTIGITsolid malignanciesNSCLCInhibitorinhibitorinhibit

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