2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species Bcl-2 Family Caspase
  4. Simazine

Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.

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Simazine Chemical Structure

Simazine Chemical Structure

CAS No. : 122-34-9

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Based on 1 publication(s) in Google Scholar

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Simazine Related Antibodies

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Description

Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice[1][2][3].

In Vitro

Simazine (200-400 μM; 9-12 h) can inhibit the maturation, disrupt the spindle morphology, affect mitochondrial function, increase the level of ROS, and induce DNA damage and early apoptosis of mouse oocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Simazine Related Antibodies
In Vivo

Simazine (0-400 mg/kg; oral gavage; 3 weeks) can lead to immunosuppression and immunotoxicity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: one-month-old healthy BALB/c mice[2]
Dosage: 0, 90, 200, or 400 mg/kg
Administration: Oral gavage; 3 weeks
Result: Reduced proliferation of both spleen T and B cells.
Decreased the number of spleen CD4+ T lymphocytes, while CD8+ T cells remained unchanged.
Reduced immune function, higher intracellular [Ca2+], and oxidative stress.
Induced spleen immune cells apoptosis by reducing Bcl-2, while increasing Fas and Caspase-3 level.
Molecular Weight

201.66

Formula

C7H12ClN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCNC1=NC(Cl)=NC(NCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (82.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9588 mL 24.7942 mL 49.5884 mL
5 mM 0.9918 mL 4.9588 mL 9.9177 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9588 mL 24.7942 mL 49.5884 mL 123.9710 mL
5 mM 0.9918 mL 4.9588 mL 9.9177 mL 24.7942 mL
10 mM 0.4959 mL 2.4794 mL 4.9588 mL 12.3971 mL
15 mM 0.3306 mL 1.6529 mL 3.3059 mL 8.2647 mL
20 mM 0.2479 mL 1.2397 mL 2.4794 mL 6.1986 mL
25 mM 0.1984 mL 0.9918 mL 1.9835 mL 4.9588 mL
30 mM 0.1653 mL 0.8265 mL 1.6529 mL 4.1324 mL
40 mM 0.1240 mL 0.6199 mL 1.2397 mL 3.0993 mL
50 mM 0.0992 mL 0.4959 mL 0.9918 mL 2.4794 mL
60 mM 0.0826 mL 0.4132 mL 0.8265 mL 2.0662 mL
80 mM 0.0620 mL 0.3099 mL 0.6199 mL 1.5496 mL
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Simazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simazine122-34-9ApoptosisReactive Oxygen SpeciesBcl-2 FamilyCaspaseherbicidephytotoxicitymouse oocytesInhibitorinhibitorinhibit

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