Anti-Mouse TIM-1/CD365 Antibody (3D10) 

Anti-Mouse TIM-1/CD365 Antibody (3D10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse TIM-1/CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can block mouse T cell immunoglobulin and mucin domain 1 (TIM-1) also known as CD365. Anti-Mouse TIM-1/CD365 Antibody (3D10) can be used for the researches of inflammation, immunology and cardiovascular disease, such as graft-versus-host disease (GVHD), airway inflammation and atherosclerosis^[1][2][3].

Rat IgG1 kappa

Rat IgG1 kappa, Isotype Control

Mouse

TIM-1/CD365

Anti-Mouse TIM-1/CD365 Antibody (3D10) (200 μg, i.p., twice a week for 4 weeks) aggravates the development of atherosclerosis companied anti-Tim-4 antibody in high fat diet ldlr^−/− mice^[1].
Anti-Mouse TIM-1/CD365 Antibody (3D10) (24 h before ozone exposure) prevents the development of ozone-induced airway hyperreactivity and airway inflammation in wildtype mice^[2].
Anti-Mouse TIM-1/CD365 Antibody (3D10) (400 μg, i.p., at days -1, 3, 7, 11, and 17) prevents graft-versus-host disease (GVHD) in lethally irradiated BALB/c (H-2^d) mice received allogeneic B6 BM and Tcon cells (H-2^b)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

171283  [NCBI]

Q5QNS5-1

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

[Anti-Mouse TIM-1/CD365 Antibody (3D10)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Foks AC, et al. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):456-65.  [Content Brief]

  [2]. Kim HY, et al. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol. 2013 Aug;132(2):414-25.e6.  [Content Brief]

  [3]. Iliopoulou BP, et al. Blockade of TIM-1 on the donor graft ameliorates graft-versus-host disease following hematopoietic cell transplantation. Blood Adv. 2019 Nov 12;3(21):3419-3431.  [Content Brief]

  [4]. Ikeda M, et al. Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope. Biochem Biophys Res Commun. 2015 Mar 20;458(4):877-82.  [Content Brief]