2. Cell Cycle/DNA Damage PI3K/Akt/mTOR Immunology/Inflammation
  3. DNA/RNA Synthesis Akt PD-1/PD-L1
  4. Chem-0199

Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

Chem-0199

Chem-0199 Chemical Structure

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Chem-0199 Related Antibodies

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Description

Chem-0199 is an Adipocyte Enhancer-Binding Protein 1 (AEBP1) inhibitor. Chem-0199 can disrupt the interaction between AEBP1 and CKAP4, thereby enhances antitumor immunity. Chem-0199 can inhibit Akt phosphorylation (p-Akt) and downregulates PD-L1 expression. Chem-0199 can be used for the research of cancer, such as colon cancer[1].

In Vitro

Chem-0199 inhibits the binding of AEBP1 to CKAP4 in human/mouse cancer-associated fibroblasts (hCAFs/mCAFs)[1].
Chem-0199 (10-100 μM) inhibits Akt phosphorylation (p-Akt) and downregulates PD-L1 expression in mCAFs[1].
Chem-0199 (10-100 μM, 48 h) significantly increases the proportion of IFN-γ+ and TNF-α+CD8+ T cells and restores T cell cytotoxicity in mouse splenic T cells[1].
Chem-0199 (1-20 μM, 72 h) shows no significant inhibitory effect on the proliferation of multiple tumor cells (MC38, CT26, B16-F10)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chem-0199 Related Antibodies
In Vivo

Chem-0199 (3-30 mg/kg, i.p.) inhibits MC38 tumor growth in WT C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: WT C57BL/6 mice with MC38 tumor [1]
Dosage: 3, 10 and 30 mg/kg
Administration: Intraperitoneally injection
Result: Reduced tumor volume.
Further enhanced tumor inhibition and prolonged mouse survival combined with anti-CTLA-4 antibody.
Increased the proportion of IFN-γ+ and TNF-α+CD8+ T cells.
Showed no abnormalities in blood routine (WBC, RBC, Hb, PLT) or H&E staining of heart, liver, lung, kidney, and intestine tissues.
Molecular Weight

234.29

Formula

C13H18N2O2
SMILES

CC1(C)N(O)[C@H](C2=CC=CC=C2)[N+]([O-])=C1CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Chem-0199 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chem-0199Chem0199Chem 0199DNA/RNA SynthesisAktPD-1/PD-L1PKBProtein kinase BPD-1/Programmed death-ligand 1AEBP1CKAP4PD-L1Colon cancerMC38Cancer-associated fibroblastsCAFsT cellInhibitorinhibitorinhibit

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