2. Immunology/Inflammation
  3. CD1
  4. Anti-Mouse CD1d Antibody (20H2 (HB323))

Anti-Mouse CD1d Antibody (20H2 (HB323)) 

Cat. No.: HY-P990807
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Anti-Mouse CD1d Antibody (20H2 (HB323)) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CD1d. Anti-Mouse CD1d Antibody (20H2 (HB323)) can block CD1d and neutralize invariant natural killer T (iNKT) cells. Anti-Mouse CD1d Antibody (20H2 (HB323)) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma, L. monocytogenes infection and arthritis.

For research use only. We do not sell to patients.

Anti-Mouse CD1d Antibody (20H2 (HB323))

Anti-Mouse CD1d Antibody (20H2 (HB323)) Chemical Structure

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Description

Anti-Mouse CD1d Antibody (20H2 (HB323)) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse CD1d. Anti-Mouse CD1d Antibody (20H2 (HB323)) can block CD1d and neutralize invariant natural killer T (iNKT) cells. Anti-Mouse CD1d Antibody (20H2 (HB323)) can be used for the researches of cancer, infection, inflammation and immunology, such as melanoma, L. monocytogenes infection and arthritis[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

CD1d
In Vivo

Anti-Mouse CD1d Antibody (20H2 (HB323)) (50 μg, i.p., 3 times a week from 7 days before tumor cell implantation) inactivates natural killer T (NKT) cells and reduces liver Metastases in B16LS9 melanoma mice[1].
Anti-Mouse CD1d Antibody (20H2 (HB323)) (500 μg, i.p., simultaneously with infection) ameliorates Listeriosis in L. monocytogenes infected mice[2].
Anti-Mouse CD1d Antibody (20H2 (HB323)) (200 μg, i.p., at days 0, 3 and 6) neutralizes invariant natural killer T (iNKT) cells and inhibits of CIA development in collagen-induced arthritis (CIA) mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16LS9 melanoma mice models[1]
Dosage: 50 μg
Administration: Intraperitoneally injection, 3 times a week from 7 days before tumor cell implantation
Result: Reduced liver Metastases.
Caused significantly higher cytotoxicity of liver NK cells.
Animal Model: Collagen-induced arthritis (CIA) mice models[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, at days 0, 3 and 6
Result: Reduced arthritis score and number of affected limbs.
Reduced joint inflammation and destruction.
Gene ID

12479  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse CD1d Antibody (20H2 (HB323))]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD1d Antibody (20H2 (HB323)) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD1d Antibody (20H2 (HB323))CD1CD1dNKTiNKTL. monocytogenesMelanomaArthritisInhibitorinhibitorinhibit

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